ID   SUP-B13
AC   CVCL_A308
SY   SUPB13
DR   Cosmic; 2348805
DR   Wikidata; Q54970858
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1434795;
RX   PubMed=1967982;
RX   PubMed=3162827;
RX   PubMed=7630190;
RX   PubMed=7888679;
RX   PubMed=8704231;
RX   PubMed=9108419;
RX   PubMed=9823951;
RX   PubMed=10071072;
CC   Population: Caucasian.
CC   Doubling time: ~35 hours (PubMed=1434795; PubMed=3162827).
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=3162827; PubMed=10071072).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C68659; Childhood B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
DI   ORDO; Orphanet_585909; B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_0103 ! SUP-B15
SX   Male
AG   9Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 16
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=1434795;
RA   Neely E.K., Rosenfeld R.G., Illescas A., Smith S.D.;
RT   "Mitogenic effects of human recombinant insulin on B-cell precursor
RT   acute lymphoblastic leukemia cells.";
RL   Leukemia 6:1134-1142(1992).
//
RX   PubMed=1967982; DOI=10.1016/0092-8674(90)90657-Z;
RA   Nourse J., Mellentin J.D., Galili N., Wilkinson J., Stanbridge E.J.,
RA   Smith S.D., Cleary M.L.;
RT   "Chromosomal translocation t(1;19) results in synthesis of a homeobox
RT   fusion mRNA that codes for a potential chimeric transcription
RT   factor.";
RL   Cell 60:535-545(1990).
//
RX   PubMed=3162827;
RA   Naumovski L., Morgan R., Hecht F., Link M.P., Glader B.E., Smith S.D.;
RT   "Philadelphia chromosome-positive acute lymphoblastic leukemia cell
RT   lines without classical breakpoint cluster region rearrangement.";
RL   Cancer Res. 48:2876-2879(1988).
//
RX   PubMed=7630190;
RA   Zhou M.-X., Gu L.-B., James C.D., He J., Yeager A.M., Smith S.D.,
RA   Findley H.W.;
RT   "Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines
RT   established from children with acute lymphoblastic leukemia.";
RL   Leukemia 9:1159-1161(1995).
//
RX   PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608;
RA   Zhou M.-X., Yeager A.M., Smith S.D., Findley H.W.;
RT   "Overexpression of the MDM2 gene by childhood acute lymphoblastic
RT   leukemia cells expressing the wild-type p53 gene.";
RL   Blood 85:1608-1614(1995).
//
RX   PubMed=8704231; DOI=10.1182/blood.V88.3.785.785;
RA   Kim D.-H., Moldwin R.L., Vignon C., Bohlander S.K., Suto Y.,
RA   Giordano L., Gupta R., Fears S., Nucifora G., Rowley J.D., Smith S.D.;
RT   "TEL-AML1 translocations with TEL and CDKN2 inactivation in acute
RT   lymphoblastic leukemia cell lines.";
RL   Blood 88:785-794(1996).
//
RX   PubMed=9108419; DOI=10.1182/blood.V89.8.2986;
RA   Findley H.W., Gu L.-B., Yeager A.M., Zhou M.-X.;
RT   "Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with
RT   p53 status and sensitivity to apoptosis in childhood acute
RT   lymphoblastic leukemia.";
RL   Blood 89:2986-2993(1997).
//
RX   PubMed=9823951; DOI=10.1038/sj.leu.2401198;
RA   Zhou M.-X., Gu L.-B., Yeager A.M., Findley H.W.;
RT   "Sensitivity to Fas-mediated apoptosis in pediatric acute
RT   lymphoblastic leukemia is associated with a mutant p53 phenotype and
RT   absence of Bcl-2 expression.";
RL   Leukemia 12:1756-1763(1998).
//
RX   PubMed=10071072; DOI=10.1016/s0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//