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Cellosaurus SUP-B2 (CVCL_A312)

Cell line name SUP-B2
Accession CVCL_A312
Resource Identification Initiative To cite this cell line use: SUP-B2 (RRID:CVCL_A312)
Comments Population: Caucasian.
Doubling time: ~30 hours (PubMed=1434795).
Sequence variations
  • Gene fusion; HGNC; 3495; ETV6 + HGNC; 50866; RNF217-AS1; Name(s)=ETV6-RNF217-AS1, ETV6-STL (PubMed=9087565).
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 5Y
Category Cancer cell line
Publications

PubMed=2875799; DOI=10.1016/0092-8674(86)90362-4
Cleary M.L., Smith S.D., Sklar J.
Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation.
Cell 47:19-28(1986)

PubMed=1434795
Neely E.K., Rosenfeld R.G., Illescas A., Smith S.D.
Mitogenic effects of human recombinant insulin on B-cell precursor acute lymphoblastic leukemia cells.
Leukemia 6:1134-1142(1992)

PubMed=8231254
Zhang L.Q., Downie P.A., Goodell W.R., McCabe N.R., Le Beau M.M., Morgan R., Sklar J., Raimondi S.C., Miley D., Goldberg A., Lu M.-M., Montag A., Smith S.D.
Establishment of cell lines from B-cell precursor acute lymphoblastic leukemia.
Leukemia 7:1865-1874(1993)

PubMed=7630190
Zhou M.-X., Gu L.-B., James C.D., He J., Yeager A.M., Smith S.D., Findley H.W.
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608
Zhou M.-X., Yeager A.M., Smith S.D., Findley H.W.
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood 85:1608-1614(1995)

PubMed=8704231; DOI=10.1182/blood.V88.3.785.785
Kim D.-H., Moldwin R.L., Vignon C., Bohlander S.K., Suto Y., Giordano L., Gupta R., Fears S., Nucifora G., Rowley J.D., Smith S.D.
TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines.
Blood 88:785-794(1996)

PubMed=9087565; DOI=10.1002/(SICI)1098-2264(199704)18:4<254::AID-GCC3>3.0.CO;2-%23
Suto Y., Sato Y., Smith S.D., Rowley J.D., Bohlander S.K.
A t(6;12)(q23;p13) results in the fusion of ETV6 to a novel gene, STL, in a B-cell ALL cell line.
Genes Chromosomes Cancer 18:254-268(1997)

PubMed=9108419; DOI=10.1182/blood.V89.8.2986
Findley H.W., Gu L.-B., Yeager A.M., Zhou M.-X.
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood 89:2986-2993(1997)

PubMed=9823951; DOI=10.1038/sj.leu.2401198
Zhou M.-X., Gu L.-B., Yeager A.M., Findley H.W.
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia 12:1756-1763(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Cross-references
Encyclopedic resources Wikidata; Q54970864
Entry history
Entry creation06-Jun-2012
Last entry update21-Mar-2023
Version number14