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Cellosaurus KBM-3 (CVCL_A425)

Cell line name KBM-3
Synonyms KBM3
Accession CVCL_A425
Resource Identification Initiative To cite this cell line use: KBM-3 (RRID:CVCL_A425)
Comments Doubling time: 22.9 hours (Note=At 255th passage) (PubMed=1568450).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=7627932).
Disease Acute myelomonocytic leukemia (NCIt: C7463)
Acute myelomonocytic leukemia (ORDO: Orphanet_517)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Female
Age at sampling 32Y
Category Cancer cell line

PubMed=1995877; DOI=10.1021/jm00106a013
Farquhar D., Newman R.A., Zuckerman J.E., Andersson B.S.
Doxorubicin analogues incorporating chemically reactive substituents.
J. Med. Chem. 34:561-564(1991)

Andersson B.S., Bergerheim U.S.R., Collins V.P., Childs C., Beran M., Sen S., Arden K.C., Pathak S., Siciliano M.J., Ost A., Freireich E.J.
KBM-3, an in vitro model of human acute myelomonocytic leukemia.
Exp. Hematol. 20:361-367(1992)

PubMed=7627932; DOI=10.1016/0165-4608(94)00282-g
Sen S., Zhou H.-Y., Andersson B.S., Cork A., Freireich E.J., Stass S.A.
p53 gene mutations with chromosome 17 abnormalities in chronic myelogenous leukemia blast crisis patients persist in long-term cell lines but may be acquired in acute myeloid leukemia cells in vitro.
Cancer Genet. Cytogenet. 82:35-40(1995)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

Cell line databases/resources cancercelllines; CVCL_A425
Chemistry resources ChEMBL-Cells; CHEMBL3307847
ChEMBL-Targets; CHEMBL614010
PubChem_Cell_line; CVCL_A425
Encyclopedic resources Wikidata; Q54899582
Polymorphism and mutation databases Cosmic; 975260
IARC_TP53; 4651
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number16