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Cellosaurus MCF-7 Tam1 (CVCL_A4AQ)

[Text version]
Cell line name MCF-7 Tam1
Synonyms MCF7/TAM1; MCF7:TAM1
Accession CVCL_A4AQ
Resource Identification Initiative To cite this cell line use: MCF-7 Tam1 (RRID:CVCL_A4AQ)
Comments Population: Caucasian.
Doubling time: ~1-2 weeks (ATCC=CRL-3435).
Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
Omics: Deep exome analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=27378269; DOI=10.1186/s12885-016-2452-5
Kangaspeska S., Hultsch S., Jaiswal A., Edgren H., Mpindi J.P., Eldfors S., Bruck O., Aittokallio T., Kallioniemi O.-P.
Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer.
BMC Cancer 16:378.1-378.17(2016)

Cross-references
Cell line collections (Providers) ATCC; CRL-3435
Cell line databases/resources cancercelllines; CVCL_A4AQ
Chemistry resources ChEMBL-Cells; CHEMBL4630711
ChEMBL-Targets; CHEMBL4630717
PubChem_Cell_line; CVCL_A4AQ
Encyclopedic resources Wikidata; Q105510077
Entry history
Entry creation12-Jan-2021
Last entry update05-Oct-2023
Version number6