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Cellosaurus NCI-H838 KRAS (G12V/+9n) (CVCL_A4IL)

[Text version]

Cell line name NCI-H838 KRAS (G12V/+9n)
Synonyms KRAS (G12V/+9n) NCI-H838
Accession CVCL_A4IL
Resource Identification Initiative To cite this cell line use: NCI-H838 KRAS (G12V/+9n) (RRID:CVCL_A4IL)
Comments Characteristics: Heterozygous knockin of a KRAS activating mutation in 10 copies.
Sequence variations Mutation; HGNC; 11110; ARID1A; Simple; p.Pro1876Serfs*22 (c.5625_5632del) (p.CPP1657fs) (c.5621_5628delGCCCACCA); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple_edited; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Heterozygous; Note=By method not specified (Horizon Discovery).
Mutation; HGNC; 11998; TP53; Simple; p.Glu62Ter (c.184G>T); ClinVar=VCV000617472; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1594 (NCI-H838)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
Cell line collections Horizon_Discovery; HD+114-003
Other Wikidata; Q105510325
Entry history
Entry creation12-Jan-2021
Last entry update20-May-2021
Version number2