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Cellosaurus NCI-H2461 (CVCL_A536)

[Text version]

Cell line name NCI-H2461
Synonyms H2461; H-2461
Accession CVCL_A536
Resource Identification Initiative To cite this cell line use: NCI-H2461 (RRID:CVCL_A536)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12
D3S135816
D5S81812
D7S8209,10
D8S117911,12
D13S3179,12
D16S5399,11
D18S5115
D21S1130
FGA20,22
Penta D12
Penta E10,11
TH016,9
TPOX8,10
vWA15,17 (Cosmic-CLP)
17 (PubMed=25877200)

Run an STR similarity search on this cell line
Publications

PubMed=7695406; DOI=10.1016/0003-4975(95)00045-M
Pass H.I., Stevens E.J., Oie H.K., Tsokos M.G., Abati A.D., Fetsch P.A., Mew D.J.Y., Pogrebniak H.W., Matthews W.J.
Characteristics of nine newly derived mesothelioma cell lines.
Ann. Thorac. Surg. 59:835-844(1995)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=23830731; DOI=10.1016/j.cancergen.2013.04.006
Klorin G., Rozenblum E., Glebov O.K., Walker R.L., Park Y., Meltzer P.S., Kirsch I.R., Kaye F.J., Roschke A.V.
Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.
Cancer Genet. 206:191-205(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line databases/resources CCLE; NCIH2461_PLEURA
Cell_Model_Passport; SIDM00102
Cosmic-CLP; 1290810
GDSC; 1290810
Ontologies EFO; EFO_0006681
Biological sample resources BioSample; SAMN03471038
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM1669820
Other Wikidata; Q54907976
Polymorphism and mutation databases Cosmic; 1032371
Cosmic; 1087353
Cosmic; 1995412