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Cellosaurus NCI-H2596 (CVCL_A546)

Cell line name NCI-H2596
Synonyms H2596; H-2596
Accession CVCL_A546
Resource Identification Initiative To cite this cell line use: NCI-H2596 (RRID:CVCL_A546)
Comments Omics: Array-based CGH.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977.
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,30:02
HLA-BB*27:05,49:01
HLA-CC*02:02,07:06
Class II
HLA-DQDQA1*01:02,01:02
DQB1*06:13,06:13
HLA-DRDRB1*13:02,15:01
Disease Pleural sarcomatoid mesothelioma (NCIt: C45663)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11
D3S135816
D5S81812
D7S8209,11
D8S117913,16
D13S31711,13
D16S53912
D18S5114
D21S1129,33.2
FGA20
Penta D12,13
Penta E12
TH016
TPOX8
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=7695406; DOI=10.1016/0003-4975(95)00045-M
Pass H.I., Stevens E.J., Oie H.K., Tsokos M.G., Abati A.D., Fetsch P.A., Mew D.J.Y., Pogrebniak H.W., Matthews W.J.
Characteristics of nine newly derived mesothelioma cell lines.
Ann. Thorac. Surg. 59:835-844(1995)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=23830731; DOI=10.1016/j.cancergen.2013.04.006
Klorin G., Rozenblum E., Glebov O.K., Walker R.L., Park Y., Meltzer P.S., Kirsch I.R., Kaye F.J., Roschke A.V.
Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.
Cancer Genet. 206:191-205(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

Cross-references
Biological sample resources BioSample; SAMN03471021
Chemistry resources GDSC; 1240133
PharmacoDB; NCIH2596_1096_2019
Encyclopedic resources Wikidata; Q54907991
Experimental variables resources EFO; EFO_0006683
Gene expression databases ArrayExpress; E-MTAB-2706
Polymorphism and mutation databases Cosmic; 1032390
Cosmic; 1087355
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number20