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Cellosaurus NCI-N592 (CVCL_A590)

[Text version]

Cell line name NCI-N592
Synonyms N592; N-592; NCI-H592; H592; H-592; NCIN592
Accession CVCL_A590
Resource Identification Initiative To cite this cell line use: NCI-N592 (RRID:CVCL_A590)
Comments Problematic cell line: Contaminated. Shown to be a NCI-H69 derivative.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00415.
Omics: Array-based CGH.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for PIK3CA p.Gly106_Arg108del (c.317_325dellGGCAACCGT) (from parent cell line).
Homozygous for RB1 p.Glu748Ter (c.2242G>T) (from parent cell line).
Homozygous for TP53 p.Glu171Ter (c.511G>T) (ClinVar=VCV000634771) (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX,Y
CSF1PO10,12
D5S81811,13
D7S8209
D13S31712
D16S53911
TH018,9
TPOX10
vWA16,17

Run an STR similarity search on this cell line
Web pages https://www.atcc.org/support/faqs/5dbd2/NCIH592%20ATCC%20CRL5832-1070.aspx
http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx
Publications

PubMed=2985257
Carney D.N., Gazdar A.F., Bepler G., Guccion J.G., Marangos P.J., Moody T.W., Zweig M.H., Minna J.D.
Establishment and identification of small cell lung cancer cell lines having classic and variant features.
Cancer Res. 45:2913-2923(1985)

PubMed=2574988; DOI=10.1038/bjc.1989.376
Jensen P.B., Vindelov L.L., Roed H., Demant E.J.F., Sehested M., Skovsgaard T., Hansen H.H.
In vitro evaluation of the potential of aclarubicin in the treatment of small cell carcinoma of the lung (SCCL).
Br. J. Cancer 60:838-844(1989)

PubMed=1563005
Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.
Neuromedin B is present in lung cancer cell lines.
Cancer Res. 52:2732s-2736s(1992)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=8806103; DOI=10.1002/jcb.240630516
Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M., Ihde D.C., Gazdar A.F.
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
J. Cell. Biochem. 63 Suppl. 24:210-217(1996)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

Cross-references
Cell line collections ATCC; CRL-5832 - Discontinued
Biological sample resources BioSample; SAMN03151861
BioSample; SAMN03471748
Chemistry resources ChEMBL-Cells; CHEMBL3307825
ChEMBL-Targets; CHEMBL613969
Gene expression databases GEO; GSM536331
GEO; GSM844664
Other Wikidata; Q54908213
Polymorphism and mutation databases Cosmic; 877210
Cosmic; 1021867
Cosmic; 1434966
Cosmic; 1998273
Entry history
Entry creation06-Jun-2012
Last entry update02-Jul-2020
Version number21