ID   NCI-N592
AC   CVCL_A590
SY   N592; N-592; NCI-H592; H592; H-592; NCIN592
DR   ATCC; CRL-5832
DR   BioSample; SAMN03151861
DR   BioSample; SAMN03471748
DR   cancercelllines; CVCL_A590
DR   ChEMBL-Cells; CHEMBL3307825
DR   ChEMBL-Targets; CHEMBL613969
DR   Cosmic; 877210
DR   Cosmic; 1021867
DR   Cosmic; 1434966
DR   Cosmic; 1998273
DR   GEO; GSM536331
DR   GEO; GSM844664
DR   Progenetix; CVCL_A590
DR   PubChem_Cell_line; CVCL_A590
DR   Wikidata; Q54908213
RX   PubMed=1563005;
RX   PubMed=2574988;
RX   PubMed=2985257;
RX   PubMed=8806092;
RX   PubMed=8806103;
RX   PubMed=11414198;
RX   PubMed=20615970;
WW   https://www.atcc.org/en/support/technical-support/faqs/nci-h592-atcc-crl-5832
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a NCI-H69 derivative.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00415.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
CC   Omics: Array-based CGH.
CC   Omics: Transcriptome analysis by microarray.
CC   Discontinued: ATCC; CRL-5832; true.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): ATCC
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 12
ST   D16S539: 11
ST   D5S818: 11,13
ST   D7S820: 9
ST   TH01: 8,9
ST   TPOX: 10
ST   vWA: 16,17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1579 ! NCI-H69
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 28
//
RX   PubMed=1563005;
RA   Giaccone G., Battey J., Gazdar A.F., Oie H.K., Draoui M., Moody T.W.;
RT   "Neuromedin B is present in lung cancer cell lines.";
RL   Cancer Res. 52:2732s-2736s(1992).
//
RX   PubMed=2574988; DOI=10.1038/bjc.1989.376;
RA   Jensen P.B., Vindelov L.L., Roed H., Demant E.J.F., Sehested M.,
RA   Skovsgaard T., Hansen H.H.;
RT   "In vitro evaluation of the potential of aclarubicin in the treatment
RT   of small cell carcinoma of the lung (SCCL).";
RL   Br. J. Cancer 60:838-844(1989).
//
RX   PubMed=2985257;
RA   Carney D.N., Gazdar A.F., Bepler G., Guccion J.G., Marangos P.J.,
RA   Moody T.W., Zweig M.H., Minna J.D.;
RT   "Establishment and identification of small cell lung cancer cell lines
RT   having classic and variant features.";
RL   Cancer Res. 45:2913-2923(1985).
//
RX   PubMed=8806092; DOI=10.1002/jcb.240630505;
RA   Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P.,
RA   McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr.,
RA   Carney D.N., Minna J.D., Mulshine J.L.;
RT   "NCI-Navy Medical Oncology Branch cell line data base.";
RL   J. Cell. Biochem. 63 Suppl. 24:32-91(1996).
//
RX   PubMed=8806103; DOI=10.1002/jcb.240630516;
RA   Johnson B.E., Russell E., Simmons A.M., Phelps R.M., Steinberg S.M.,
RA   Ihde D.C., Gazdar A.F.;
RT   "MYC family DNA amplification in 126 tumor cell lines from patients
RT   with small cell lung cancer.";
RL   J. Cell. Biochem. 63 Suppl. 24:210-217(1996).
//
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H.,
RA   Wolf E., Gabius H.-J.;
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
//
RX   PubMed=20615970; DOI=10.1073/pnas.1008132107;
RA   Voortman J., Lee J.-H., Killian J.K., Suuriniemi M., Wang Y.-H.,
RA   Lucchi M., Smith W.I. Jr., Meltzer P.S., Wang Y.-S., Giaccone G.;
RT   "Array comparative genomic hybridization-based characterization of
RT   genetic alterations in pulmonary neuroendocrine tumors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:13040-13045(2010).
//