ID   Hep-G2 VL-17A
AC   CVCL_A5CT
SY   HepG2 VL-17A; VL-17A; VL17A
DR   BTO; BTO:0006458
DR   Wikidata; Q107115329
RX   PubMed=16181800;
RX   PubMed=22436864;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 2631; CYP2E1.
CC   Transfected with: MGI; MGI:87921; Adh1.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transfected with: UniProtKB; P17493; S.hindustanus ble.
CC   Derived from sampling site: Liver.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_A5CQ ! Hep-G2 VA-13
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 23-09-21; Version: 2
//
RX   PubMed=16181800; DOI=10.1016/j.biocel.2005.07.010;
RA   Donohue T.M., Osna N.A., Clemens D.L.;
RT   "Recombinant Hep G2 cells that express alcohol dehydrogenase and
RT   cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity.";
RL   Int. J. Biochem. Cell Biol. 38:92-101(2006).
//
RX   PubMed=22436864; DOI=10.1039/c2ib00155a;
RA   Chandrasekaran K., Swaminathan K., Kumar S.M., Clemens D.L., Dey A.;
RT   "Increased oxidative stress and toxicity in ADH and CYP2E1
RT   overexpressing human hepatoma VL-17A cells exposed to high glucose.";
RL   Integr. Biol. (Camb.) 4:550-563(2012).
//