Cellosaurus logo
expasy logo

Cellosaurus HEK293T-GIGYF1/2-null (CVCL_A5EG)

[Text version]
Cell line name HEK293T-GIGYF1/2-null
Synonyms GIGYF1/2-null HEK293T
Accession CVCL_A5EG
Resource Identification Initiative To cite this cell line use: HEK293T-GIGYF1/2-null (RRID:CVCL_A5EG)
Comments Doubling time: ~30-40 hours (DSMZ=ACC-874).
Knockout cell: Method=CRISPR/Cas9; HGNC; 9126; GIGYF1.
Knockout cell: Method=CRISPR/Cas9; HGNC; 11960; GIGYF2.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=tsA].
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0063 (HEK293T)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO11,12
D2S133819
D3S135815,16,17
D5S8188,9
D7S82011
D8S117912,14
D13S31712
D16S5399,13
D18S5118
D19S43317,18,19
D21S1128,30
FGA23
Penta D9,10,11
Penta E7,15
TH017,9.3
TPOX11
vWA16,18,19

Run an STR similarity search on this cell line
Publications

PubMed=28698298; DOI=10.1101/gad.299420.117
Peter D., Weber R., Sandmeir F., Wohlbold L., Helms S., Bawankar P., Valkov E., Igreja C., Izaurralde E.
GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.
Genes Dev. 31:1147-1161(2017)

PubMed=31439631; DOI=10.1101/gad.329219.119
Peter D., Ruscica V., Bawankar P., Weber R., Helms S., Valkov E., Igreja C., Izaurralde E.
Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.
Genes Dev. 33:1355-1360(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-874
Cell line databases/resources DSMZCellDive; ACC-874
Encyclopedic resources Wikidata; Q107115308
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number6