ID   U-251MG IDH1 WT
AC   CVCL_A5HR
SY   U251(WT); U251WT
DR   cancercelllines; CVCL_A5HR
DR   MetaboLights; MTBLS1973
DR   Wikidata; Q107117148
RX   PubMed=33504762;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
CC   Transfected with: HGNC; 5382; IDH1.
CC   Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0021 ! U-251MG
SX   Male
AG   75Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 6
//
RX   PubMed=33504762; DOI=10.1038/s41467-020-20752-6;
RA   Lita A., Pliss A., Kuzmin A., Yamasaki T., Zhang L.-M., Dowdy T.,
RA   Burks C., de Val N., Celiku O., Ruiz-Rodado V., Nicoli E.-R.,
RA   Kruhlak M., Andresson T., Das S., Yang C.-Z., Schmitt R.,
RA   Herold-Mende C., Gilbert M.R., Prasad P.N., Larion M.;
RT   "IDH1 mutations induce organelle defects via dysregulated
RT   phospholipids.";
RL   Nat. Commun. 12:614.1-614.16(2021).
//