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Cellosaurus CHO-K1 Mev-1 (CVCL_A5KD)

[Text version]
Cell line name CHO-K1 Mev-1
Synonyms Mev-1
Accession CVCL_A5KD
Resource Identification Initiative To cite this cell line use: CHO-K1 Mev-1 (RRID:CVCL_A5KD)
Comments Characteristics: Deficient for mevalonate biosynthesis. Lacks hydroxymethylglutaryl-CoA synthase activity (PubMed=4019518).
Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_7182 (CHO Pro-3)
Children:
CVCL_A5KE (CHO-K1 Mev-SM)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=6118375; DOI=10.1016/S0021-9258(19)68388-2
Schnitzer-Polokoff R., von Gunten C., Logel J., Torget R.W., Sinensky M.
Isolation and characterization of a mammalian cell mutant defective in 3-hydroxy-3-methylglutaryl coenzyme A synthase.
J. Biol. Chem. 257:472-476(1982)

PubMed=4019518; DOI=10.1016/S0021-9258(17)39191-3
Peffley D., Sinensky M.
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis by a non-sterol mevalonate-derived product in Mev-1 cells Apparent translational control.
J. Biol. Chem. 260:9949-9952(1985)

PubMed=7961793; DOI=10.1016/S0021-9258(19)61932-0
Ortiz J.A., Gil-Gomez G., Casaroli-Marano R.P., Vilaro S., Hegardt F.G., Haro D.
Transfection of the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase cDNA into Mev-1 cells corrects their auxotrophy for mevalonate.
J. Biol. Chem. 269:28523-28526(1994)

Cross-references
Encyclopedic resources Wikidata; Q107114656
Entry history
Entry creation20-May-2021
Last entry update30-Jan-2024
Version number6