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Cellosaurus COLO 320DM#3 (CVCL_A6UJ)

[Text version]
Cell line name COLO 320DM#3
Synonyms COLO 320DM #3; COLO 320 (DM) subclone 3
Accession CVCL_A6UJ
Resource Identification Initiative To cite this cell line use: COLO 320DM#3 (RRID:CVCL_A6UJ)
Comments Population: Caucasian.
Characteristics: Contains multiple DMs with amplified MYC (PubMed=3164477).
Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Ser811Ter (c.2432C>G); ClinVar=VCV002203685; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0219 (COLO 320DM)
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=3164477; DOI=10.1073/pnas.85.13.4804
Von Hoff D.D., Needham-VanDevanter D.R., Yucel J., Windle B.E., Wahl G.M.
Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.
Proc. Natl. Acad. Sci. U.S.A. 85:4804-4808(1988)

PubMed=31569279; DOI=10.1002/gcc.22810
Oobatake Y., Shimizu N.
Double-strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation.
Genes Chromosomes Cancer 59:133-143(2020)

PubMed=33539925; DOI=10.1016/j.jbc.2021.100356
Taniguchi R., Utani K., Thakur B., Ishine K., Aladjem M.I., Shimizu N.
SIRT1 stabilizes extrachromosomal gene amplification and contributes to repeat-induced gene silencing.
J. Biol. Chem. 296:100356.1-100356.12(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A6UJ
Encyclopedic resources Wikidata; Q107114695
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number5