Cellosaurus cell line UPN1 (CVCL_A795)

• Gene deletion; HGNC; 9884; RB1; Zygosity=Homozygous (PubMed=17332242).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Glu286Lys (c.856G>A); ClinVar=VCV000183752; Zygosity=Homozygous (PubMed=16960149; PubMed=17332242).
  

PubMed=12742154; DOI=10.1016/S0165-4608(02)00823-3
M'kacher R., Farace F., Bennaceur-Griscelli A., Violot D., Clausse B., Dossou J., Valent A., Parmentier C., Ribrag V., Bosq J., Carde P., Turhan A.G., Bernheim A.
Blastoid mantle cell lymphoma: evidence for nonrandom cytogenetic abnormalities additional to t(11;14) and generation of a mouse model.
Cancer Genet. Cytogenet. 143:32-38(2003)

PubMed=12970738; DOI=10.1038/sj.onc.1206826
M'kacher R., Bennaceur-Griscelli A., Farace F., Lauge A., Plassa L.F., Wittmer E., Dossou J., Violot D., Deutsch E., Bourhis J., Stoppa-Lyonnet D., Ribrag V., Carde P., Parmentier C., Bernheim A., Turhan A.G.
Multiple molecular mechanisms contribute to radiation sensitivity in mantle cell lymphoma.
Oncogene 22:7905-7912(2003)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F., Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=17332242; DOI=10.1182/blood-2006-11-057208
Pinyol M., Bea S., Pla L., Ribrag V., Bosq J., Rosenwald A., Campo E., Jares P.
Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis.
Blood 109:5422-5429(2007)

PubMed=21746927; DOI=10.1073/pnas.1018941108
Beltran E., Fresquet V., Martinez-Useros J., Richter-Larrea J.A., Sagardoy A., Sesma I., Almada L.L., Montes-Moreno S., Siebert R., Gesk S., Calasanz M.J., Malumbres R., Rieger M., Prosper F., Lossos I.S., Piris M.A., Fernandez-Zapico M.E., Martinez-Climent J.A.
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)

PubMed=25688540; DOI=10.1002/cyto.a.22643
Maiga S., Brosseau C., Descamps G., Dousset C., Gomez-Bougie P., Chiron D., Menoret E., Kervoelen C., Vie H., Cesbron A., Moreau-Aubry A., Amiot M., Pellat-Deceunynck C.
A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
Cytometry A 87:285-288(2015)