ID   UPN1
AC   CVCL_A795
SY   UPN-1
DR   cancercelllines; CVCL_A795
DR   Cosmic; 1047109
DR   Cosmic; 2296996
DR   GEO; GSM119542
DR   GEO; GSM155075
DR   GEO; GSM155076
DR   GEO; GSM155077
DR   GEO; GSM629500
DR   GEO; GSM629501
DR   GEO; GSM2322623
DR   IARC_TP53; 25020
DR   Progenetix; CVCL_A795
DR   Wikidata; Q54991714
RX   PubMed=12742154;
RX   PubMed=12970738;
RX   PubMed=16960149;
RX   PubMed=17332242;
RX   PubMed=21746927;
RX   PubMed=25688540;
CC   HLA typing: A*24,32; B*07,18; C*07,07 (PubMed=25688540).
CC   Sequence variation: Gene deletion; HGNC; 9884; RB1; Zygosity=Homozygous (PubMed=17332242).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu286Lys (c.856G>A); ClinVar=VCV000183752; Zygosity=Homozygous (PubMed=16960149; PubMed=17332242).
CC   Omics: Array-based CGH.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4337; Mantle cell lymphoma
DI   ORDO; Orphanet_52416; Mantle cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 18
//
RX   PubMed=12742154; DOI=10.1016/S0165-4608(02)00823-3;
RA   M'kacher R., Farace F., Bennaceur-Griscelli A., Violot D., Clausse B.,
RA   Dossou J., Valent A., Parmentier C., Ribrag V., Bosq J., Carde P.,
RA   Turhan A.G., Bernheim A.;
RT   "Blastoid mantle cell lymphoma: evidence for nonrandom cytogenetic
RT   abnormalities additional to t(11;14) and generation of a mouse
RT   model.";
RL   Cancer Genet. Cytogenet. 143:32-38(2003).
//
RX   PubMed=12970738; DOI=10.1038/sj.onc.1206826;
RA   M'kacher R., Bennaceur-Griscelli A., Farace F., Lauge A., Plassa L.F.,
RA   Wittmer E., Dossou J., Violot D., Deutsch E., Bourhis J.,
RA   Stoppa-Lyonnet D., Ribrag V., Carde P., Parmentier C., Bernheim A.,
RA   Turhan A.G.;
RT   "Multiple molecular mechanisms contribute to radiation sensitivity in
RT   mantle cell lymphoma.";
RL   Oncogene 22:7905-7912(2003).
//
RX   PubMed=16960149; DOI=10.1182/blood-2006-06-026500;
RA   Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R.,
RA   Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M.,
RA   Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F.,
RA   Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S.,
RA   Martinez-Climent J.A.;
RT   "Homozygous deletions localize novel tumor suppressor genes in B-cell
RT   lymphomas.";
RL   Blood 109:271-280(2007).
//
RX   PubMed=17332242; DOI=10.1182/blood-2006-11-057208;
RA   Pinyol M., Bea S., Pla L., Ribrag V., Bosq J., Rosenwald A., Campo E.,
RA   Jares P.;
RT   "Inactivation of RB1 in mantle-cell lymphoma detected by
RT   nonsense-mediated mRNA decay pathway inhibition and microarray
RT   analysis.";
RL   Blood 109:5422-5429(2007).
//
RX   PubMed=21746927; DOI=10.1073/pnas.1018941108;
RA   Beltran E., Fresquet V., Martinez-Useros J., Richter-Larrea J.A.,
RA   Sagardoy A., Sesma I., Almada L.L., Montes-Moreno S., Siebert R.,
RA   Gesk S., Calasanz M.J., Malumbres R., Rieger M., Prosper F.,
RA   Lossos I.S., Piris M.A., Fernandez-Zapico M.E.,
RA   Martinez-Climent J.A.;
RT   "A cyclin-D1 interaction with BAX underlies its oncogenic role and
RT   potential as a therapeutic target in mantle cell lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011).
//
RX   PubMed=25688540; DOI=10.1002/cyto.a.22643;
RA   Maiga S., Brosseau C., Descamps G., Dousset C., Gomez-Bougie P.,
RA   Chiron D., Menoret E., Kervoelen C., Vie H., Cesbron A.,
RA   Moreau-Aubry A., Amiot M., Pellat-Deceunynck C.;
RT   "A simple flow cytometry-based barcode for routine authentication of
RT   multiple myeloma and mantle cell lymphoma cell lines.";
RL   Cytometry A 87:285-288(2015).
//