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Cellosaurus SHSY-5Y Tet-On SNCA (CVCL_A7QJ)

[Text version]

Cell line name SHSY-5Y Tet-On SNCA
Synonyms SHSY-5Y Tet-On Inducible Alpha-Synuclein
Accession CVCL_A7QJ
Resource Identification Initiative To cite this cell line use: SHSY-5Y Tet-On SNCA (RRID:CVCL_A7QJ)
Comments Characteristics: Inducible expression of SNCA upon treatment with doxycycline. Serves as a model for both dopaminergic neuronal biology and a-synuclein pathology (Millipore).
Characteristics: Transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16.
Transfected with: HGNC; 11138; SNCA.
Transfected with: UniProtKB; P04483; E.coli Tn10 tetR.
Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with del 1-360).
Sequence variations Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Derived from metastatic site: Bone marrow.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0019 (SH-SY5Y)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): Millipore

Markers:
AmelogeninX
CSF1PO11
D3S135815,16
D5S81812
D7S8207,10
D8S117915
D13S31711
D16S5398,13
D18S5113,16
D21S1131,31.2
FGA23.2,24
Penta D10,12
Penta E7,11
TH017,10
TPOX8,11
vWA14,18

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Cross-references
Cell line collections Millipore; SCC291
Other Wikidata; Q107116922
Entry history
Entry creation20-May-2021
Last entry update23-Sep-2021
Version number2