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Cellosaurus A549-hACE2 [BEI resources] (CVCL_A7UV)

[Text version]
Cell line name A549-hACE2 [BEI resources]
Accession CVCL_A7UV
Resource Identification Initiative To cite this cell line use: A549-hACE2 [BEI resources] (RRID:CVCL_A7UV)
Comments Group: SARS-CoV-2 research cell line.
From: Baric R.; Department of Epidemiology, University of North Carolina at Chapel Hill; Chapel Hill; USA.
Population: Caucasian.
Characteristics: Expresses ACE2 under the control of the EF1a promoter (BEI_Resources=NR-53821).
Transfected with: HGNC; 13557; ACE2.
Transfected with: UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Children:
CVCL_D1JI (A549-AC)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) BEI_Resources; NR-53821
Cell line databases/resources cancercelllines; CVCL_A7UV
Encyclopedic resources Wikidata; Q107113334
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number5