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Cellosaurus HepG2-8960-R (CVCL_A8FS)

[Text version]

Cell line name HepG2-8960-R
Accession CVCL_A8FS
Resource Identification Initiative To cite this cell line use: HepG2-8960-R (RRID:CVCL_A8FS)
Comments Population: Caucasian.
Characteristics: Radioresistant. Can proliferate with daily exposure to 2 Gy X-rays for more than 30 days (PubMed=19215227).
Transformant: NCIt; C17262; X-Ray.
Derived from sampling site: Liver.
Sequence variations Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line

PubMed=19215227; DOI=10.1111/j.1349-7006.2009.01082.x
Kuwahara Y., Li L., Baba T., Nakagawa H., Shimura T., Yamamoto Y., Ohkubo Y., Fukumoto M.
Clinically relevant radioresistant cells efficiently repair DNA double-strand breaks induced by X-rays.
Cancer Sci. 100:747-752(2009)

PubMed=20410675; DOI=10.1269/jrr.09094
Kuwahara Y., Mori M., Oikawa T., Shimura T., Ohtake Y., Mori S., Ohkubo Y., Fukumoto M.
The modified high-density survival assay is the useful tool to predict the effectiveness of fractionated radiation exposure.
J. Radiat. Res. 51:297-302(2010)

PubMed=21716292; DOI=10.1038/cddis.2011.56
Kuwahara Y., Oikawa T., Ochiai Y., Roudkenar M.H., Fukumoto M., Shimura T., Ohtake Y., Ohkubo Y., Mori S., Uchiyama Y., Fukumoto M.
Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy.
Cell Death Dis. 2:e177.1-e177.11(2011)

PubMed=27681752; DOI=10.1016/j.ijrobp.2016.07.002
Kuwahara Y., Roudkenar M.H., Suzuki M., Urushihara Y., Fukumoto M., Saito Y., Fukumoto M.
The involvement of mitochondrial membrane potential in cross-resistance between radiation and docetaxel.
Int. J. Radiat. Oncol. Biol. Phys. 96:556-565(2016)

Other Wikidata; Q107115333
Entry history
Entry creation20-May-2021
Last entry update23-Sep-2021
Version number2