ID   HepG2-8960-R
AC   CVCL_A8FS
DR   Wikidata; Q107115333
RX   PubMed=19215227;
RX   PubMed=20410675;
RX   PubMed=21716292;
RX   PubMed=27681752;
CC   Population: Caucasian.
CC   Characteristics: Radioresistant. Can proliferate with daily exposure to 2 Gy X-rays for more than 30 days (PubMed=19215227).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from sampling site: Liver.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 23-09-21; Version: 2
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RX   PubMed=19215227; DOI=10.1111/j.1349-7006.2009.01082.x;
RA   Kuwahara Y., Li L., Baba T., Nakagawa H., Shimura T., Yamamoto Y.,
RA   Ohkubo Y., Fukumoto M.;
RT   "Clinically relevant radioresistant cells efficiently repair DNA
RT   double-strand breaks induced by X-rays.";
RL   Cancer Sci. 100:747-752(2009).
//
RX   PubMed=20410675; DOI=10.1269/jrr.09094;
RA   Kuwahara Y., Mori M., Oikawa T., Shimura T., Ohtake Y., Mori S.,
RA   Ohkubo Y., Fukumoto M.;
RT   "The modified high-density survival assay is the useful tool to
RT   predict the effectiveness of fractionated radiation exposure.";
RL   J. Radiat. Res. 51:297-302(2010).
//
RX   PubMed=21716292; DOI=10.1038/cddis.2011.56;
RA   Kuwahara Y., Oikawa T., Ochiai Y., Roudkenar M.H., Fukumoto M.,
RA   Shimura T., Ohtake Y., Ohkubo Y., Mori S., Uchiyama Y., Fukumoto M.;
RT   "Enhancement of autophagy is a potential modality for tumors
RT   refractory to radiotherapy.";
RL   Cell Death Dis. 2:e177.1-e177.11(2011).
//
RX   PubMed=27681752; DOI=10.1016/j.ijrobp.2016.07.002;
RA   Kuwahara Y., Roudkenar M.H., Suzuki M., Urushihara Y., Fukumoto M.,
RA   Saito Y., Fukumoto M.;
RT   "The involvement of mitochondrial membrane potential in
RT   cross-resistance between radiation and docetaxel.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 96:556-565(2016).
//