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Cellosaurus CLC12N2 (CVCL_A8GH)

[Text version]

Cell line name CLC12N2
Accession CVCL_A8GH
Resource Identification Initiative To cite this cell line use: CLC12N2 (RRID:CVCL_A8GH)
Comments Transfected with: HGNC; 16412; NLRC4 (with p.Leu152_Ala1024del, CARD domain, C12N2 construct).
Transfected with: HGNC; 5331; NOD2 (with p.Met1_Ala216del, NACHT+LRR domains, C12N2 construct).
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Sequence variations Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 2514; CTNNB1; Simple; p.Asn287Ser (c.860A>G); ClinVar=VCV000133954; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Tyr103fs*37 (c.308_321delTGTGTAACAGTTCC); Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0218 (COLO 205)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
STR profile Source(s): TKG

Markers:
AmelogeninX
CSF1PO11,12
D5S81810,13
D7S8209,10
D13S31710,12
D16S53912,13
TH018,9
TPOX11
vWA15

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Publications

PubMed=20500518; DOI=10.1111/j.1349-7006.2010.01610.x
Motani K., Kawase K., Imamura R., Kinoshita T., Kushiyama H., Suda T.
Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication.
Cancer Sci. 101:1822-1827(2010)

Cross-references
Cell line collections TKG; TKG 0802
Other Wikidata; Q107114691
Entry history
Entry creation20-May-2021
Last entry update23-Sep-2021
Version number2