ID   CLC12N2
AC   CVCL_A8GH
DR   cancercelllines; CVCL_A8GH
DR   TKG; TKG 0802
DR   Wikidata; Q107114691
RX   PubMed=20500518;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Asn287Ser (c.860A>G); ClinVar=VCV000133954; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr103fs*37 (c.308_321delTGTGTAACAGTTCC); Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 16412; NLRC4 (with p.Leu152_Ala1024del, CARD domain, C12N2 construct).
CC   Transfected with: HGNC; 5331; NOD2 (with p.Met1_Ala216del, NACHT+LRR domains, C12N2 construct).
CC   Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
ST   Source(s): TKG
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 10,12
ST   D16S539: 12,13
ST   D5S818: 10,13
ST   D7S820: 9,10
ST   TH01: 8,9
ST   TPOX: 11
ST   vWA: 15
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0218 ! COLO 205
SX   Male
AG   70Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 05-10-23; Version: 5
//
RX   PubMed=20500518; DOI=10.1111/j.1349-7006.2010.01610.x;
RA   Motani K., Kawase K., Imamura R., Kinoshita T., Kushiyama H., Suda T.;
RT   "Activation of ASC induces apoptosis or necrosis, depending on the
RT   cell type, and causes tumor eradication.";
RL   Cancer Sci. 101:1822-1827(2010).
//