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Cellosaurus S1-IR20 (CVCL_A9DE)

[Text version]
Cell line name S1-IR20
Accession CVCL_A9DE
Resource Identification Initiative To cite this cell line use: S1-IR20 (RRID:CVCL_A9DE)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:80630; Irinotecan (Camptothecin-11; CPT-11).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0H88 (S1)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=33692943; DOI=10.3389/fonc.2020.624954
Wu Z.-X., Yang Y.-Q., Zeng L.-L., Patel H., Bo L.-T., Lin L.-S., Chen Z.-S.
Establishment and characterization of an irinotecan-resistant human colon cancer cell line.
Front. Oncol. 10:624954.1-624954.8(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9DE
Encyclopedic resources Wikidata; Q108821254
Entry history
Entry creation23-Sep-2021
Last entry update05-Oct-2023
Version number5