Home  |  Contact

Cellosaurus WM983B-BR (CVCL_AP81)

[Text version]
Cell line name WM983B-BR
Synonyms WM983B BR; WM983BBR; WM983B-R
Accession CVCL_AP81
Resource Identification Initiative To cite this cell line use: WM983B-BR (RRID:CVCL_AP81)
Comments Part of: Wistar Institute melanoma cell line collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:131882; SB-590885.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Inguinal lymph node; UBERON=UBERON_0001542.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=21156289; Wistar).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro278Phe (c.832_833CC>TT); Zygosity=Homozygous (from parent cell line).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6809 (WM983B)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn
Publications

PubMed=21156289; DOI=10.1016/j.ccr.2010.11.023
Villanueva J., Vultur A., Lee J.T., Somasundaram R., Fukunaga-Kalabis M., Cipolla A.K., Wubbenhorst B., Xu X.-W., Gimotty P.A., Kee D., Santiago-Walker A.E., Letrero R., D'Andrea K., Pushparajan A., Hayden J.E., Dahlman K.B., Laquerre S.G., McArthur G.A., Sosman J.A., Nathanson K.L., Herlyn M.
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)

PubMed=23285177; DOI=10.1371/journal.pone.0052760
Schayowitz A.B., Bertenshaw G.P., Jeffries E., Schatz T., Cotton J., Villanueva J., Herlyn M., Krepler C., Vultur A., Xu W., Yu G.H., Schuchter L.M., Clark D.P.
Functional profiling of live melanoma samples using a novel automated platform.
PLoS ONE 7:E52760-E52760(2012)

Cross-references
Cell line collections (Providers) Rockland; WM983BBR-01-0001
Cell line databases/resources cancercelllines; CVCL_AP81
Encyclopedic resources Wikidata; Q54994347
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number15