Cellosaurus 451Lu-BR (CVCL_AP83)

Cell line name 451Lu-BR
Synonyms 451Lu BR; 451LU BR; 451LuBR; 451Lu-R
Accession CVCL_AP83
Resource Identification Initiative To cite this cell line use: 451Lu-BR (RRID:CVCL_AP83)
Comments Part of: Wistar Institute melanoma cell line collection.
Selected for resistance to: ChEBI; CHEBI:131882; SB-590885.
Sequence variations Heterozygous for BRAF p.Val600Glu (c.1799T>A) (Wistar).
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6357 (451Lu)
Sex of cell Male
Age at sampling 22Y
Category Cancer cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn

PubMed=21156289; DOI=10.1016/j.ccr.2010.11.023
Villanueva J., Vultur A., Lee J.T., Somasundaram R., Fukunaga-Kalabis M., Cipolla A.K., Wubbenhorst B., Xu X., Gimotty P.A., Kee D., Santiago-Walker A.E., Letrero R., D'Andrea K., Pushparajan A., Hayden J.E., Brown K.D., Laquerre S.G., McArthur G.A., Sosman J.A., Nathanson K.L., Herlyn M.
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)