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Cellosaurus 451Lu-BR (CVCL_AP83)

Cell line name 451Lu-BR
Synonyms 451Lu BR; 451LU BR; 451LuBR; 451Lu-R; 451Lu R
Accession CVCL_AP83
Resource Identification Initiative To cite this cell line use: 451Lu-BR (RRID:CVCL_AP83)
Comments Part of: Wistar Institute melanoma cell line collection.
Selected for resistance to: ChEBI; CHEBI:131882; SB-590885.
Sequence variations Heterozygous for BRAF p.Val600Glu (c.1799T>A) (PubMed=21156289; Wistar).
TP53 p.Tyr220Cys (c.659A>G) (PubMed=21156289).
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6357 (451Lu)
Sex of cell Male
Age at sampling 22Y
Category Cancer cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn

PubMed=21156289; DOI=10.1016/j.ccr.2010.11.023
Villanueva J., Vultur A., Lee J.T., Somasundaram R., Fukunaga-Kalabis M., Cipolla A.K., Wubbenhorst B., Xu X., Gimotty P.A., Kee D., Santiago-Walker A.E., Letrero R., D'Andrea K., Pushparajan A., Hayden J.E., Brown K.D., Laquerre S.G., McArthur G.A., Sosman J.A., Nathanson K.L., Herlyn M.
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)

PubMed=23285177; DOI=10.1371/journal.pone.0052760
Schayowitz A., Bertenshaw G., Jeffries E., Schatz T., Cotton J., Villanueva J., Herlyn M., Krepler C., Vultur A., Xu W., Yu G.H., Schuchter L., Clark D.P.
Functional profiling of live melanoma samples using a novel automated platform.
PLoS ONE 7:E52760-E52760(2012)

Other Wikidata; Q54603181