Cellosaurus SK-MEL-28-VR (CVCL_AP99)

Cell line name SK-MEL-28-VR
Accession CVCL_AP99
Resource Identification Initiative To cite this cell line use: SK-MEL-28-VR (RRID:CVCL_AP99)
Comments Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
Sequence variation: Homozygous for BRAF p.Val600Glu (from parent cell line).
Sequence variation: Heterozygous for CDK4 p.Arg24Cys (from parent cell line).
Sequence variation: Homozygous for EGFR p.Pro753Ser (from parent cell line).
Sequence variation: Homozygous for TP53 p.Leu145Arg (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0526 (SK-MEL-28)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=26497853; DOI=10.18632/oncotarget.5755
Fofaria N.M., Frederick D.T., Sullivan R.J., Flaherty K.T., Srivastava S.K.
Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma.
Oncotarget 6:40535-40556(2015)