Cellosaurus SK-MEL-28-VR (CVCL_AP99)

Cell line name SK-MEL-28-VR
Accession CVCL_AP99
Resource Identification Initiative To cite this cell line use: SK-MEL-28-VR (RRID:CVCL_AP99)
Comments Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
Sequence variations Homozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
Heterozygous for CDK4 p.Arg24Cys (from parent cell line).
Homozygous for EGFR p.Pro753Ser (from parent cell line).
PTEN p.Thr167Ala (from parent cell line).
Homozygous for TP53 p.Leu145Arg (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0526 (SK-MEL-28)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=26497853; DOI=10.18632/oncotarget.5755
Fofaria N.M., Frederick D.T., Sullivan R.J., Flaherty K.T., Srivastava S.K.
Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma.
Oncotarget 6:40535-40556(2015)