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Cellosaurus BT-474 Clone 5 (CVCL_AQ07)

[Text version]

Cell line name BT-474 Clone 5
Synonyms BT474 clone 5
Accession CVCL_AQ07
Resource Identification Initiative To cite this cell line use: BT-474 Clone 5 (RRID:CVCL_AQ07)
Comments Selected for resistance to: DrugBank; DB00072; Trastuzumab (Herceptin).
Sequence variations Heterozygous for MAPK1 p.His61Gln (c.183C>G) (from parent cell line).
Heterozygous for PIK3CA p.Lys111Asn (c.333G>C) (ClinVar=VCV000376483) (from parent cell line).
Homozygous for TP53 p.Glu285Lys (c.853G>A) (ClinVar=VCV000420133) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0179 (BT-474)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line
Publications

PubMed=14750129; DOI=10.1002/cyto.a.10095
Kute T., Lack C.M., Willingham M., Bishwokama B., Williams H., Barrett K., Mitchell T., Vaughn J.P.
Development of Herceptin resistance in breast cancer cells.
Cytometry A 57:86-93(2004)

Cross-references
Cell line collections ATCC; CRL-3247
Other Wikidata; Q54798462
Entry history
Entry creation02-May-2016
Last entry update02-Jul-2020
Version number9