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Cellosaurus COG-N-415 (CVCL_AQ23)

[Text version]
Cell line name COG-N-415
Synonyms COGN415
Accession CVCL_AQ23
Resource Identification Initiative To cite this cell line use: COG-N-415 (RRID:CVCL_AQ23)
Comments Doubling time: 50 hours (COG).
Omics: Chromatin accessibility by ATAC-seq.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (PubMed=28350380).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): COG

Markers:
AmelogeninX
CSF1PO10,11
D2S133819,21
D3S135814,15
D5S81811
D7S8209,10
D8S117911,13,14
D13S31711,12
D16S53911
D18S5112,15
D19S43314,15
D21S1128,29
FGA19,22
TH017,8
TPOX11
vWA17

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Publications

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Farooqi A.S., Dagg R.A., Choi L.M.R., Shay J.W., Reynolds C.P., Lau L.M.S.
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

PubMed=28340497; DOI=10.1002/ijc.30706
Lopez-Barcons L., Maurer B.J., Kang M.H., Reynolds C.P.
P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models.
Int. J. Cancer 141:405-413(2017)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AQ23
Encyclopedic resources Wikidata; Q54814023
Gene expression databases GEO; GSM2371224
GEO; GSM4104571
GEO; GSM4104572
GEO; GSM4104624
GEO; GSM4104625
GEO; GSM4105303
GEO; GSM4105304
GEO; GSM4105305
GEO; GSM4105306
GEO; GSM4105307
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number12