ID   HCEC 1CT
AC   CVCL_AQ45
SY   HCEC-1CT; hCEC-1CT; 1CT-HCEC; Human Colonic Epithelial Cells 1 transduced with CDK4 and Telomerase; 1CT
DR   EFO; EFO_0009500
DR   ENCODE; ENCBS573VIG
DR   ENCODE; ENCBS654NDM
DR   Wikidata; Q54881860
RX   PubMed=19962984;
RX   PubMed=21527559;
RX   PubMed=21472139;
RX   PubMed=25923178;
RX   PubMed=27047802;
WW   https://evercyte.com/hcec-1ct/
CC   Doubling time: 18-24 hours (Evercyte).
CC   Transfected with: HGNC; 1773; CDK4.
CC   Transfected with: HGNC; 11730; TERT.
CC   Omics: Deep exome analysis.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
ST   Source(s): PubMed=27047802
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 12,13
ST   D16S539: 10,11
ST   D21S11: 28
ST   D5S818: 11,14
ST   D7S820: 9,11
ST   TH01: 9.3
ST   TPOX: 11
ST   vWA: 16,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   54Y
CA   Telomerase immortalized cell line
DT   Created: 02-05-16; Last updated: 29-06-23; Version: 10
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RX   PubMed=19962984; DOI=10.1053/j.gastro.2009.11.052;
RA   Roig A.I., Eskiocak U., Hight S.K., Kim S.B., Delgado O., Souza R.F.,
RA   Spechler S.J., Wright W.E., Shay J.W.;
RT   "Immortalized epithelial cells derived from human colon biopsies
RT   express stem cell markers and differentiate in vitro.";
RL   Gastroenterology 138:1012-1021(2010).
//
RX   PubMed=21527559; DOI=10.1158/0008-5472.CAN-11-0794;
RA   Eskiocak U., Kim S.B., Ly P., Roig A.I., Biglione S., Komurov K.,
RA   Cornelius C., Wright W.E., White M.A., Shay J.W.;
RT   "Functional parsing of driver mutations in the colorectal cancer
RT   genome reveals numerous suppressors of anchorage-independent growth.";
RL   Cancer Res. 71:4359-4365(2011).
//
RX   PubMed=21472139; DOI=10.1593/neo.101580;
RA   Ly P., Eskiocak U., Kim S.B., Roig A.I., Hight S.K., Lulla D.R.,
RA   Zou Y.S., Batten K.G., Wright W.E., Shay J.W.;
RT   "Characterization of aneuploid populations with trisomy 7 and 20
RT   derived from diploid human colonic epithelial cells.";
RL   Neoplasia 13:348-357(2011).
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RX   PubMed=25923178; DOI=10.1186/1471-2164-16-S1-S8;
RA   Zhang L., Kim S., Jia G.-X., Buhmeida A., Dallol A., Wright W.E.,
RA   Fornace A.J. Jr., Al-Qahtani M., Shay J.W.;
RT   "Exome sequencing of normal and isogenic transformed human colonic
RT   epithelial cells (HCECs) reveals novel genes potentially involved in
RT   the early stages of colorectal tumorigenesis.";
RL   BMC Genomics 16 Suppl. 1:S8.1-S8.8(2015).
//
RX   PubMed=27047802; DOI=10.3389/fcimb.2016.00034;
RA   Graillot V., Dormoy I., Dupuy J., Shay J.W., Huc L., Mirey G.,
RA   Vignard J.;
RT   "Genotoxicity of cytolethal distending toxin (CDT) on isogenic human
RT   colorectal cell lines: potential promoting effects for colorectal
RT   carcinogenesis.";
RL   Front. Cell. Infect. Microbiol. 6:34.1-34.13(2016).
//