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Cellosaurus TK6 (IVGT) (CVCL_AR68)

[Text version]
Cell line name TK6 (IVGT)
Synonyms TK6(IVGT)
Accession CVCL_AR68
Resource Identification Initiative To cite this cell line use: TK6 (IVGT) (RRID:CVCL_AR68)
Comments Part of: In Vitro Genetic Toxicity (IVGT) cell line panel.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Omics: SNP array analysis.
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Sequence variations
  • Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (PubMed=33198927).
  • Mutation; HGNC; 11830; TK1; Simple; p.Ala78Argfs*27 (c.231insC); Zygosity=Heterozygous (PubMed=33198927).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0561 (TK6)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
STR profile Source(s): ECACC

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81812,13
D7S8209,11
D13S31711
D16S53911,12
TH018,9.3
TPOX8,11
vWA17,20

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Publications

PubMed=27692294; DOI=10.1016/j.mrgentox.2016.08.001
Lorge E., Moore M.M., Clements J., O'Donovan M., Fellows M.D., Honma M., Kohara A., Galloway S., Armstrong M.J., Thybaud V., Gollapudi B., Aardema M.J., Tanir J.Y.
Standardized cell sources and recommendations for good cell culture practices in genotoxicity testing.
Mutat. Res. 809:1-15(2016)

PubMed=29892436; DOI=10.1098/rsos.172472
Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M., Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S., Satoh M., Shimizu N., Kohara A.
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

PubMed=33198927; DOI=10.1016/j.mrgentox.2020.503236
Kasai F., Hirayama N., Kohara A.
TK6 genome profile compared with WIL2-NS: reference data to improve the reproducibility of genotoxicity studies.
Mutat. Res. 858:503236.1-503236.7(2020)

Cross-references
Cell line collections (Providers) ECACC; 13051501
JCRB; JCRB1435
Encyclopedic resources Wikidata; Q54972536
Gene expression databases GEO; GSM4288410
Entry history
Entry creation02-May-2016
Last entry update29-Jun-2023
Version number12