ID   HCT 116 BRCA2(-/-) clone 42
AC   CVCL_AS10
SY   HCT 116 BRCA2 -/- [42]; HCT 116 BRCA2-/-
DR   cancercelllines; CVCL_AS10
DR   CancerTools; 152628
DR   ECACC; 16071901
DR   Wikidata; Q54881923
DR   Ximbio; 152628
RX   PubMed=25043256;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; 1101; BRCA2.
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): ECACC
ST   Amelogenin: X,Y
ST   CSF1PO: 7,10
ST   D13S317: 10,13
ST   D16S539: 11,13
ST   D18S51: 16,17
ST   D21S11: 29,30
ST   D3S1358: 12,13
ST   D5S818: 10,11
ST   D7S820: 11,12
ST   D8S1179: 12,14
ST   FGA: 18,23
ST   Penta D: 9,13
ST   Penta E: 13,14
ST   TH01: 8,9
ST   TPOX: 8
ST   vWA: 17,21
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 05-10-23; Version: 15
//
RX   PubMed=25043256; DOI=10.1002/path.4404;
RA   Xu H., Xian J., Vire E., McKinney S., Wei V., Wong J., Tong R.,
RA   Kouzarides T., Caldas C., Aparicio S.;
RT   "Up-regulation of the interferon-related genes in BRCA2 knockout
RT   epithelial cells.";
RL   J. Pathol. 234:386-397(2014).
//