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Cellosaurus 786-O/Luc (CVCL_AS74)

[Text version]

Cell line name 786-O/Luc
Synonyms 786-0/Luciferase
Accession CVCL_AS74
Resource Identification Initiative To cite this cell line use: 786-O/Luc (RRID:CVCL_AS74)
Comments Characteristics: Expression of luciferase is under the control of the CMV promoter.
Transfected with: UniProtKB; P08659; Firefly luciferase (pRev_CMV_Luc2).
Sequence variations Homozygous for PTEN p.Gln149Ter (c.445C>T) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Heterozygous for TP53 c.560-2A>G; splice acceptor mutation and p.Pro278Ala (c.832C>G) (ClinVar=VCV000376645) (from parent cell line).
Homozygous for VHL p.Gly104fs*55 (c.311delG) (from parent cell line).
Disease Renal cell carcinoma (NCIt: C9385)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1051 (786-O)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line

PubMed=20443133; DOI=10.1007/s10585-010-9329-9
Strube A., Stepina E., Mumberg D., Scholz A., Hauff P., Kakonen S.-M.
Characterization of a new renal cell carcinoma bone metastasis mouse model.
Clin. Exp. Metastasis 27:319-330(2010)

Other Wikidata; Q54604953
Entry history
Entry creation02-May-2016
Last entry update02-Jul-2020
Version number9