Cellosaurus cell line KRIB (CVCL_AU05)

• Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
  

CLPUB00319
Samid D., Mandler R.
Human osteosarcoma cells transformed by ras-oncogenes: a new model for in vivo studies of pulmonary metastasis.
Clin. Biotechnol. 1:21-26(1989)

PubMed=8402677
Berlin O., Samid D., Donthineni-Rao R., Akeson W.H., Amiel D., Woods V.L. Jr.
Development of a novel spontaneous metastasis model of human osteosarcoma transplanted orthotopically into bone of athymic mice.
Cancer Res. 53:4890-4895(1993)

PubMed=22075555; DOI=10.1158/0008-5472.CAN-11-2778
Huang G.-X., Yu L., Cooper L.J.N., Hollomon M., Huls H., Kleinerman E.S.
Genetically modified T cells targeting interleukin-11 receptor alpha-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases.
Cancer Res. 72:271-281(2012)

PubMed=24136885; DOI=10.1002/pbc.24801
Guma S.R., Lee D.A., Yu L., Gordon N., Hughes D., Stewart J., Wang W.-L., Kleinerman E.S.
Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis.
Pediatr. Blood Cancer 61:618-626(2014)

PubMed=26320182; DOI=10.18632/oncotarget.5177
Ren L., Mendoza A., Zhu J., Briggs J.W., Halsey C., Hong E.S., Burkett S.S., Morrow J.J., Lizardo M.M., Osborne T., Li S.Q., Luu H.H., Meltzer P.S., Khanna C.
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
Oncotarget 6:29469-29481(2015)