ID   NCI-H226Br
AC   CVCL_AX73
SY   H226Br; H226br; 226Br
DR   BTO; BTO:0000171
DR   cancercelllines; CVCL_AX73
DR   Wikidata; Q54907949
RX   PubMed=7634243;
RX   PubMed=8089864;
RX   PubMed=8528963;
RX   PubMed=8956792;
RX   PubMed=9498829;
CC   Population: Caucasian.
CC   Characteristics: Established from brain metastasis tumor of athymic BALB/c mice after carotid artery injection of parent cell line.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ile254Val (c.760A>G); ClinVar=VCV000406605; Zygosity=Homozygous (PubMed=8089864).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C45662; Pleural epithelioid mesothelioma
DI   ORDO; Orphanet_50251; Pleural mesothelioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1544 ! NCI-H226
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 05-10-23; Version: 11
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RX   PubMed=7634243; DOI=10.1016/0304-3835(95)03845-N;
RA   Hwang C.-C., Fang K., Li L.-M., Shih S.H.;
RT   "Insulin-like growth factor-I is an autocrine regulator for the brain
RT   metastatic variant of a human non-small cell lung cell line.";
RL   Cancer Lett. 94:157-163(1995).
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RX   PubMed=8089864; DOI=10.1093/jnci/86.19.1458;
RA   Fujiwara T., Cai D.-W., Georges R.N., Mukhopadhyay T., Grimm E.A.,
RA   Roth J.A.;
RT   "Therapeutic effect of a retroviral wild-type p53 expression vector in
RT   an orthotopic lung cancer model.";
RL   J. Natl. Cancer Inst. 86:1458-1462(1994).
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RX   PubMed=8528963;
RA   Cai D.-W., Mukhopadhyay T., Roth J.A.;
RT   "Suppression of lung cancer cell growth by ribozyme-mediated
RT   modification of p53 pre-mRNA.";
RL   Cancer Gene Ther. 2:199-205(1995).
//
RX   PubMed=8956792; DOI=10.1038/bjc.1996.629;
RA   Fang K.;
RT   "An enhanced and sensitive autocrine stimulation by transforming
RT   growth factor-alpha is acquired in the brain metastatic variant of a
RT   human non-small-cell lung cancer cell line.";
RL   Br. J. Cancer 74:1776-1782(1996).
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RX   PubMed=9498829; DOI=10.1007/s004320050127;
RA   Perdomo J.A., Naomoto Y., Haisa M., Fujiwara T., Hamada M.,
RA   Yasuoka Y., Tanaka N.;
RT   "In vivo influence of p53 status on proliferation and
RT   chemoradiosensitivity in non-small-cell lung cancer.";
RL   J. Cancer Res. Clin. Oncol. 124:10-18(1998).
//