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Cellosaurus H3122 CR1 (CVCL_AY53)

[Text version]

Cell line name H3122 CR1
Accession CVCL_AY53
Resource Identification Initiative To cite this cell line use: H3122 CR1 (RRID:CVCL_AY53)
Comments Selected for resistance to: ChEBI; CHEBI:64310; Crizotinib (Xalkori).
Sequence variations EML4-ALK gene fusion (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5160 (NCI-H3122)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line

PubMed=21502504; DOI=10.1073/pnas.1019559108
Katayama R., Khan T.M., Benes C., Lifshits E., Ebi H., Rivera V.M., Shakespeare W.C., Iafrate A.J., Engelman J.A., Shaw A.T.
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.
Proc. Natl. Acad. Sci. U.S.A. 108:7535-7540(2011)

PubMed=24675041; DOI=10.1158/2159-8290.CD-13-0846
Friboulet L., Li N., Katayama R., Lee C.C., Gainor J.F., Crystal A.S., Michellys P.-Y., Awad M.M., Yanagitani N., Kim S., Pferdekamper A.C., Li J., Kasibhatla S., Sun F., Sun X., Hua S., McNamara P., Mahmood S., Lockerman E.L., Fujita N., Nishio M., Harris J.L., Shaw A.T., Engelman J.A.
The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer.
Cancer Discov. 4:662-673(2014)

Other Wikidata; Q54872053
Entry history
Entry creation02-May-2016
Last entry updated05-Jul-2019
Version number3