| Cell line name |
MeWo FOTE 4 |
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| Synonyms |
MeWo FOTE 4.0; MeWo-fotemustine 4 |
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| Accession |
CVCL_AZ75 |
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| Resource Identification Initiative |
To cite this cell line use: MeWo FOTE 4 (RRID:CVCL_AZ75) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:131848; Fotemustine (Mustophoran).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027. |
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| Sequence variations |
- Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Cutaneous melanoma (NCIt: C3510) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0445 (MeWo) |
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| Sex of cell |
Male |
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| Age at sampling |
78Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=11058868; DOI=10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V
Grottke C., Mantwill K., Dietel M., Schadendorf D., Lage H.
Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs.
Int. J. Cancer 88:535-546(2000) PubMed=21475863; DOI=10.3892/mmr_00000134
Surowiak P., Drag M., Materna V., Dietel M., Lage H.
Betulinic acid exhibits stronger cytotoxic activity on the normal melanocyte NHEM-neo cell line than on drug-resistant and drug-sensitive MeWo melanoma cell lines.
Mol. Med. Rep. 2:543-548(2009) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_AZ75
|
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| Encyclopedic resources |
Wikidata; Q54905341
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| Entry history |
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| Entry creation | 02-May-2016 |
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| Last entry update | 30-Jan-2024 |
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| Version number | 12 |
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