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Cellosaurus MeWo FOTE 40 (CVCL_AZ76)

[Text version]
Cell line name MeWo FOTE 40
Synonyms MeWo FOTE; MeWo-fotemustine 40
Accession CVCL_AZ76
Resource Identification Initiative To cite this cell line use: MeWo FOTE 40 (RRID:CVCL_AZ76)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:131848; Fotemustine (Mustophoran).
Omics: Proteome analysis by 2D-DE.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6877; MAPK3; Simple; p.Pro246Ser (c.736C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Unspecified (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0445 (MeWo)
Sex of cell Male
Age at sampling 78Y
Category Cancer cell line
Publications

PubMed=11001322; DOI=10.1002/1522-2683(20000801)21:14<3048::AID-ELPS3048>3.0.CO;2-W
Sinha P., Kohl S., Fischer J., Hutter G., Kern M., Kottgen E., Dietel M., Lage H., Schnolzer M., Schadendorf D.
Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis.
Electrophoresis 21:3048-3057(2000)

PubMed=11058868; DOI=10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V
Grottke C., Mantwill K., Dietel M., Schadendorf D., Lage H.
Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs.
Int. J. Cancer 88:535-546(2000)

PubMed=21475863; DOI=10.3892/mmr_00000134
Surowiak P., Drag M., Materna V., Dietel M., Lage H.
Betulinic acid exhibits stronger cytotoxic activity on the normal melanocyte NHEM-neo cell line than on drug-resistant and drug-sensitive MeWo melanoma cell lines.
Mol. Med. Rep. 2:543-548(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AZ76
Encyclopedic resources Wikidata; Q54905343
Entry history
Entry creation02-May-2016
Last entry update30-Jan-2024
Version number12