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Cellosaurus LUHMES (CVCL_B056)

[Text version]

Cell line name LUHMES
Synonyms LUnd Human MESencephalic
Accession CVCL_B056
Resource Identification Initiative To cite this cell line use: LUHMES (RRID:CVCL_B056)
Comments Characteristics: Embryonic neuronal precursor cells that can be maintained as proliferating cells due to the expression of a tetracycline-regulatable (Tet-Off) v-myc transgene. Can be differentiated to post-mitotic neurons by the addition of tetracycline, GDNF and dibutyryl cAMP.
Transfected with: UniProtKB; P01110; Avian myelocytomatosis virus MC29 v-Myc.
Transformant: v-Myc.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B061 (MESC2.10)
Children:
CVCL_HL95 (mitoLUHMES)
Sex of cell Female
Age at sampling 8FW
Category Conditionally immortalized cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO13,14
D5S81811,13
D7S82011,13
D13S3179,11
D16S53911,12
TH017,9.3
TPOX8
vWA14,17

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Publications

PubMed=16000623; DOI=10.1523/JNEUROSCI.1746-05.2005
Lotharius J., Falsig J., van Beek J., Payne S., Dringen R., Brundin P., Leist M.
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.
J. Neurosci. 25:6329-6342(2005)

PubMed=21434924; DOI=10.1111/j.1471-4159.2011.07255.x
Scholz D., Poltl D., Genewsky A., Weng M., Waldmann T., Schildknecht S., Leist M.
Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line.
J. Neurochem. 119:957-971(2011)

PubMed=24173167; DOI=10.14573/altex.2013.4.427
Schildknecht S., Karreman C., Poltl D., Efremova L., Kullmann C., Gutbier S., Krug A., Scholz D., Gerding H.R., Leist M.
Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases.
ALTEX 30:427-444(2013)

PubMed=30602607; DOI=10.1128/JVI.02210-18
Edwards T.G., Bloom D.C.
Lund human mesencephalic (LUHMES) neuronal cell line supports HSV-1 latency in vitro.
J. Virol. 93:0-0(2019)

Cross-references
Cell line collections ABM; T0284
ATCC; CRL-2927
Biological sample resources BioSample; SAMN03471701
BioSample; SAMN08723614
Other Wikidata; Q54903259