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Cellosaurus SK-N-MC-IXC/VCR (CVCL_B0FD)

[Text version]
Cell line name SK-N-MC-IXC/VCR
Synonyms MC-IXC/VCR
Accession CVCL_B0FD
Resource Identification Initiative To cite this cell line use: SK-N-MC-IXC/VCR (RRID:CVCL_B0FD)
Comments Problematic cell line: Misclassified. Grand-parent cell line (SK-N-MC) was originally thought to be a neuroblastoma cell line but shown to be from an Askin tumor.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28445; Vincristine (VCR).
Derived from site: Metastatic; Orbital region; UBERON=UBERON_0004088.
Sequence variations
  • Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.170_572del; Zygosity=Unspecified (from parent cell line).
Disease Askin tumor (NCIt: C7542)
Peripheral primitive neuroectodermal tumor (ORDO: Orphanet_370348)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1398 (SK-N-MC-IXC)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
Publications

PubMed=2566379
Meyers M.B., Rittmann-Grauer L., O'Brien J.P., Safa A.R.
Characterization of monoclonal antibodies recognizing a Mr 180,000 P-glycoprotein: differential expression of the Mr 180,000 and Mr 170,000 P-glycoproteins in multidrug-resistant human tumor cells.
Cancer Res. 49:3209-3214(1989)

Cross-references
Encyclopedic resources Wikidata; Q108821309
Entry history
Entry creation23-Sep-2021
Last entry update05-Oct-2023
Version number6