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Cellosaurus ID1-V-LUC hES (CVCL_B0JB)

[Text version]

Cell line name ID1-V-LUC hES
Synonyms CGMCC11091
Accession CVCL_B0JB
Resource Identification Initiative To cite this cell line use: ID1-V-LUC hES (RRID:CVCL_B0JB)
Comments Group: Patented cell line.
Registration: International Depositary Authority, China General Microbiological Culture Collection Center; CGMCC No.11091.
Characteristics: Stem cell model for screening drugs for pulmonary hypertension and to find a novel lead compound for the treatment of pulmonary hypertension using BMP signaling.
Characteristics: Transduced with a Id1-Venus-Luc-MC1-DTA construct in which expression of the genes for Venus and luciferase are under the control of a full-length human ID1 promoter.
Transfected with: Venus, a bright yellow fluorescent protein derived from YFP.
Transfected with: UniProtKB; P08659; Firefly luciferase.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_9773 (WA09)
Sex of cell Female
Age at sampling Blastocyst stage
Category Somatic stem cell
Publications

Patent=US20180172669
Yang Y., Zhou F., Gong S.-Q., Wei Q.-X., Zhao S., Si S.-Y.
Screening and use of piperidino pyrazolopyrimidine compound.
Patent number US20180172669, 21-Jun-2018

PubMed=29449428; DOI=10.1183/13993003.02229-2017
Xing Y.-Z., Zhao S., Wei Q.-X., Gong S.-Q., Zhao X., Zhou F., Al-Lamki R., Ortmann D., Du M.-X., Pedersen R., Shang G.-D., Si S.-Y., Morrell N.W., Yang J.
A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels.
Eur. Respir. J. 51:1702229-1702229(2018)

Cross-references
Encyclopedic resources Wikidata; Q108820530
Entry history
Entry creation23-Sep-2021
Last entry update23-Jun-2022
Version number3