ID   ID1-V-LUC hES
AC   CVCL_B0JB
SY   CGMCC11091
DR   Wikidata; Q108820530
RX   Patent=US20180172669;
RX   PubMed=29449428;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, China General Microbiological Culture Collection Center; CGMCC No.11091.
CC   Characteristics: Stem cell model for screening drugs for pulmonary hypertension and to find a novel lead compound for the treatment of pulmonary hypertension using BMP signaling.
CC   Characteristics: Transduced with a Id1-Venus-Luc-MC1-DTA construct in which expression of the genes for Venus and luciferase are under the control of a full-length human ID1 promoter.
CC   Transfected with: Venus, a bright yellow fluorescent protein derived from YFP.
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_9773 ! WA09
SX   Female
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 23-09-21; Last updated: 29-06-23; Version: 6
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RX   Patent=US20180172669;
RA   Yang Y., Zhou F., Gong S.-Q., Wei Q.-X., Zhao S., Si S.-Y.;
RT   "Screening and use of piperidino pyrazolopyrimidine compound.";
RL   Patent number US20180172669, 21-Jun-2018.
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RX   PubMed=29449428; DOI=10.1183/13993003.02229-2017;
RA   Xing Y.-Z., Zhao S., Wei Q.-X., Gong S.-Q., Zhao X., Zhou F.,
RA   Al-Lamki R., Ortmann D., Du M.-X., Pedersen R., Shang G.-D., Si S.-Y.,
RA   Morrell N.W., Yang J.;
RT   "A novel piperidine identified by stem cell-based screening attenuates
RT   pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels.";
RL   Eur. Respir. J. 51:1702229-1702229(2018).
//