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Cellosaurus SKOV3-TAX/CBP (CVCL_B0WE)

[Text version]
Cell line name SKOV3-TAX/CBP
Accession CVCL_B0WE
Resource Identification Initiative To cite this cell line use: SKOV3-TAX/CBP (RRID:CVCL_B0WE)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:31355; Carboplatin (CBP; Paraplatin).
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=34535163; DOI=10.1186/s13048-021-00873-2
Zhang J., Xie S.-H., Zhou L., Tang X.-Y., Guan X.-L., Deng M.-J., Zheng H., Wang Y.-C., Lu R.-Q., Guo L.
Up-regulation of GSTT1 in serous ovarian cancer associated with resistance to TAXOL / carboplatin.
J. Ovarian Res. 14:122.1-122.14(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B0WE
Encyclopedic resources Wikidata; Q108821312
Entry history
Entry creation23-Sep-2021
Last entry update05-Oct-2023
Version number5