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Cellosaurus HUES 6 (CVCL_B194)

[Text version]

Cell line name HUES 6
Synonyms HUES-6; HUES6; HuES6; Hues6; HVRDe006-A
Accession CVCL_B194
Resource Identification Initiative To cite this cell line use: HUES 6 (RRID:CVCL_B194)
Comments From: Harvard University; Boston; USA.
Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0019.
Registration: Swiss research registry; BAG-hES-IMP-0038.
Registration: UK Stem Cell Bank (UKSCB); R-06-009, Steering comm. appl. SCSC04-25(6).
Doubling time: 24 hours (PubMed=14999088).
Omics: DNA methylation analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K36me3 ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: H3K9ac ChIP-seq epigenome analysis.
Omics: H3K9me3 ChIP-seq epigenome analysis.
Omics: Transcriptome analysis.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_YN14 (HVRDe006-A-1)CVCL_YN72 (HVRDe006-A-4)CVCL_YN73 (HVRDe006-A-6)
Sex of cell Female
Age at sampling Blastocyst stage
Category Embryonic stem cell
STR profile Source(s): PubMed=19200798; PubMed=21637780; PubMed=28677534

Markers:
AmelogeninX
CSF1PO11,12
D1S165615,18.3
D2S133823,24
D3S135816,18
D5S81812
D6S104311,13
D7S8208,11
D8S117910,13
D12S39124,25
D13S31711
D16S53910,11
D18S5112,14
D19S43313,15
D21S1130
FGA23,24
Penta D9,10
Penta E12
TH018,9.3
TPOX9,11
vWA15,16

Run an STR similarity search on this cell line
Web pages https://grants.nih.gov/stem_cells/registry/current.htm?id=37
Publications

PubMed=14999088; DOI=10.1056/NEJMsr040330
Cowan C.A., Klimanskaya I., McMahon J., Atienza J., Witmyer J., Zucker J.P., Wang S., Morton C.C., McMahon A.P., Powers D., Melton D.A.
Derivation of embryonic stem-cell lines from human blastocysts.
N. Engl. J. Med. 350:1353-1356(2004)

PubMed=17572666; DOI=10.1038/nbt1318
Adewumi O., Aflatoonian B., Ahrlund-Richter L., Amit M., Andrews P.W., Beighton G., Bello P.A., Benvenisty N., Berry L.S., Bevan S., Blum B., Brooking J., Chen K.G., Choo A.B.H., Churchill G.A., Corbel M., Damjanov I., Draper J.S., Dvorak P., Emanuelsson K., Fleck R.A., Ford A., Gertow K., Gertsenstein M., Gokhale P.J., Hamilton R.S., Hampl A., Healy L.E., Hovatta O., Hyllner J., Imreh M.P., Itskovitz-Eldor J., Jackson J., Johnson J.L., Jones M., Kee K., King B.L., Knowles B.B., Lako M., Lebrin F., Mallon B.S., Manning D., Mayshar Y., McKay R.D.G., Michalska A.E., Mikkola M., Mileikovsky M., Minger S.L., Moore H.D., Mummery C.L., Nagy A., Nakatsuji N., O'Brien C.M., Oh S.K.W., Olsson C., Otonkoski T., Park K.-Y., Passier R., Patel H., Patel M., Pedersen R., Pera M.F., Piekarczyk M.S., Pera R.A.R., Reubinoff B.E., Robins A.J., Rossant J., Rugg-Gunn P., Schulz T.C., Semb H., Sherrer E.S., Siemen H., Stacey G.N., Stojkovic M., Suemori H., Szatkiewicz J., Turetsky T., Tuuri T., van den Brink S., Vintersten K., Vuoristo S., Ward D., Weaver T.A., Young L.A., Zhang W.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
Nat. Biotechnol. 25:803-816(2007)

PubMed=19200798; DOI=10.1016/j.stem.2008.12.001
Chen A.E., Egli D., Niakan K.K., Deng J., Akutsu H., Yamaki M., Cowan C., Fitz-Gerald C., Zhang K., Melton D.A., Eggan K.
Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines.
Cell Stem Cell 4:103-106(2009)

PubMed=21295703; DOI=10.1016/j.cell.2010.12.032
Bock C., Kiskinis E., Verstappen G., Gu H., Boulting G., Smith Z.D., Ziller M., Croft G.F., Amoroso M.W., Oakley D.H., Gnirke A., Eggan K., Meissner A.
Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.
Cell 144:439-452(2011)

PubMed=21637780; DOI=10.1371/journal.pgen.1002085
Nishino K., Toyoda M., Yamazaki-Inoue M., Fukawatase Y., Chikazawa E., Sakaguchi H., Akutsu H., Umezawa A.
DNA methylation dynamics in human induced pluripotent stem cells over time.
PLoS Genet. 7:E1002085-E1002085(2011)

PubMed=28677534; DOI=10.1016/j.scr.2017.03.015
Marczenke M., Fell J., Piccini I., Ropke A., Seebohm G., Greber B.
Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation.
Stem Cell Res. 21:26-28(2017)

Cross-references
Cell line databases/resources hPSCreg; HVRDe006-A
ISCR; 107
SKIP; SKIP001484
SKIP; SKIP001910
Ontologies EFO; EFO_0007086
Biological sample resources BioSamples; SAMEA7771168
eagle-i; harvard.eagle-i.net/i/00000140-2fd8-19b3-a870-ad6980000000
ENCODE; ENCBS153ORV
ENCODE; ENCBS271TBU
ENCODE; ENCBS530IZG
ENCODE; ENCBS912XKA
Gene expression databases GEO; GSM525424
GEO; GSM525425
GEO; GSM525426
GEO; GSM608012
GEO; GSM621700
GEO; GSM637760
GEO; GSM669885
GEO; GSM669886
GEO; GSM669887
GEO; GSM669888
GEO; GSM669889
GEO; GSM669890
GEO; GSM669891
GEO; GSM669892
GEO; GSM669893
GEO; GSM669894
GEO; GSM669895
GEO; GSM669897
GEO; GSM669898
GEO; GSM670080
GEO; GSM1112774
GEO; GSM1112776
GEO; GSM1153528
Other Wikidata; Q54896798
Entry history
Entry creation06-Jun-2012
Last entry update02-Jul-2020
Version number20