ID   KhES-3
AC   CVCL_B233
SY   KHES-3; KhES3; KUIMSe003-A
DR   GEO; GSM1040239
DR   GEO; GSM1040309
DR   GEO; GSM1489247
DR   GEO; GSM1489259
DR   GEO; GSM1489458
DR   GEO; GSM1942576
DR   GEO; GSM1942580
DR   GEO; GSM1942581
DR   GEO; GSM1942582
DR   GEO; GSM1942583
DR   GEO; GSM1942584
DR   GEO; GSM1942585
DR   GEO; GSM1942586
DR   GEO; GSM1942587
DR   hPSCreg; KUIMSe003-A
DR   ISCR; 552
DR   RCB; HES0003
DR   SKIP; SKIP000152
DR   SKIP; SKIP001954
DR   Wikidata; Q54899877
RX   PubMed=17572666;
RX   PubMed=21098095;
RX   PubMed=21460823;
RX   PubMed=22802639;
RX   PubMed=24259714;
RX   PubMed=25665923;
RX   PubMed=27476965;
RX   PubMed=33059130;
RX   PubMed=33225099;
RX   PubMed=35754715;
WW   http://www.nbrp.jp/report/reportProjectEn.jsp?project=esCell
CC   From: Institute for Frontier Medical Sciences, Kyoto University; Kyoto; Japan.
CC   Omics: DNA methylation analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 17
//
RX   PubMed=17572666; DOI=10.1038/nbt1318;
RA   Adewumi O., Aflatoonian B., Ahrlund-Richter L., Amit M., Andrews P.W.,
RA   Beighton G., Bello P.A., Benvenisty N., Berry L.S., Bevan S., Blum B.,
RA   Brooking J., Chen K.G., Choo A.B.-H., Churchill G.A., Corbel M.,
RA   Damjanov I., Draper J.S., Dvorak P., Emanuelsson K., Fleck R.A.,
RA   Ford A., Gertow K., Gertsenstein M., Gokhale P.J., Hamilton R.S.,
RA   Hampl A., Healy L.E., Hovatta O., Hyllner J., Imreh M.P.,
RA   Itskovitz-Eldor J., Jackson J., Johnson J.L., Jones M., Kee K.,
RA   King B.L., Knowles B.B., Lako M., Lebrin F., Mallon B.S., Manning D.,
RA   Mayshar Y., McKay R.D.G., Michalska A.E., Mikkola M., Mileikovsky M.,
RA   Minger S.L., Moore H.D., Mummery C.L., Nagy A., Nakatsuji N.,
RA   O'Brien C.M., Oh S.K.-W., Olsson C., Otonkoski T., Park K.-Y.,
RA   Passier R., Patel H., Patel M.J., Pedersen R., Pera M.F.,
RA   Piekarczyk M.S., Reijo Pera R.A., Reubinoff B.E., Robins A.J.,
RA   Rossant J., Rugg-Gunn P., Schulz T.C., Semb H., Sherrer E.S., Siemen H.,
RA   Stacey G.N., Stojkovic M., Suemori H., Szatkiewicz J., Turetsky T.T.,
RA   Tuuri T., van den Brink S., Vintersten K., Vuoristo S.,
RA   Ward-van Oostwaard D., Weaver T.A., Young L.A., Zhang W.-D.;
RT   "Characterization of human embryonic stem cell lines by the
RT   International Stem Cell Initiative.";
RL   Nat. Biotechnol. 25:803-816(2007).
//
RX   PubMed=21098095; DOI=10.1084/jem.20100844;
RA   Takayama N., Nishimura S., Nakamura S., Shimizu T., Ohnishi R.,
RA   Endo H., Yamaguchi T., Otsu M., Nishimura K., Nakanishi M.,
RA   Sawaguchi A., Nagai R., Takahashi K., Yamanaka S., Nakauchi H.,
RA   Eto K.;
RT   "Transient activation of c-MYC expression is critical for efficient
RT   platelet generation from human induced pluripotent stem cells.";
RL   J. Exp. Med. 207:2817-2830(2010).
//
RX   PubMed=21460823; DOI=10.1038/nmeth.1591;
RA   Okita K., Matsumura Y., Sato Y., Okada A., Morizane A., Okamoto S.,
RA   Hong H.-J., Nakagawa M., Tanabe K., Tezuka K.-i., Shibata T.,
RA   Kunisada T., Takahashi M., Takahashi J., Saji H., Yamanaka S.;
RT   "A more efficient method to generate integration-free human iPS
RT   cells.";
RL   Nat. Methods 8:409-412(2011).
//
RX   PubMed=22802639; DOI=10.1073/pnas.1209979109;
RA   Kajiwara M., Aoi T., Okita K., Takahashi R., Inoue H., Takayama N.,
RA   Endo H., Eto K., Toguchida J., Uemoto S., Yamanaka S.;
RT   "Donor-dependent variations in hepatic differentiation from
RT   human-induced pluripotent stem cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12538-12543(2012).
//
RX   PubMed=24259714; DOI=10.1073/pnas.1319061110;
RA   Koyanagi-Aoi M., Ohnuki M., Takahashi K., Okita K., Noma H.,
RA   Sawamura Y., Teramoto I., Narita M., Sato Y., Ichisaka T., Amano N.,
RA   Watanabe A., Morizane A., Yamada Y., Sato T., Takahashi J.,
RA   Yamanaka S.;
RT   "Differentiation-defective phenotypes revealed by large-scale analyses
RT   of human pluripotent stem cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20569-20574(2013).
//
RX   PubMed=25665923; DOI=10.1016/j.scr.2015.01.007;
RA   Toyoda T., Mae S.-i., Tanaka H., Kondo Y., Funato M., Hosokawa Y.,
RA   Sudo T., Kawaguchi Y., Osafune K.;
RT   "Cell aggregation optimizes the differentiation of human ESCs and
RT   iPSCs into pancreatic bud-like progenitor cells.";
RL   Stem Cell Res. 14:185-197(2015).
//
RX   PubMed=27476965; DOI=10.1016/j.stem.2016.06.019;
RA   Nishizawa M., Chonabayashi K., Nomura M., Tanaka A., Nakamura M.,
RA   Inagaki A., Nishikawa M., Takei I., Oishi A., Tanabe K., Ohnuki M.,
RA   Yokota H., Koyanagi-Aoi M., Okita K., Watanabe A., Takaori-Kondo A.,
RA   Yamanaka S., Yoshida Y.;
RT   "Epigenetic variation between human induced pluripotent stem cell
RT   lines is an indicator of differentiation capacity.";
RL   Cell Stem Cell 19:341-354(2016).
//
RX   PubMed=33059130; DOI=10.1016/j.scr.2020.102020;
RA   Kawase E., Takada K., Suemori H.;
RT   "Kyoto hESC cell resource for regenerative medicine.";
RL   Stem Cell Res. 49:102020-102020(2020).
//
RX   PubMed=33225099; DOI=10.31662/jmaj.2018-0029;
RA   Umezawa A., Sato Y., Kusakawa S., Amagase R., Akutsu H., Nakamura K.,
RA   Kasahara M., Matsubara Y., Igarashi T.;
RT   "Research and development strategy for future embryonic stem cell-
RT   based therapy in Japan.";
RL   JMA J. 3:287-294(2020).
//
RX   PubMed=35754715; DOI=10.1016/j.isci.2022.104538;
RA   Yamane J., Wada T., Otsuki H., Inomata K., Suzuki M., Hisaki T.,
RA   Sekine S., Kouzuki H., Kobayashi K., Sone H., Yamashita J.K.,
RA   Osawa M., Saito M.K., Fujibuchi W.;
RT   "StemPanTox: a fast and wide-target drug assessment system for
RT   tailor-made safety evaluations using personalized iPS cells.";
RL   IScience 25:104538.1-104538.23(2022).
//