Cellosaurus PC-9 (CVCL_B260)

Cell line name PC-9
Synonyms PC9; PC-9/S1; PC-9S1
Accession CVCL_B260
Resource Identification Initiative To cite this cell line use: PC-9 (RRID:CVCL_B260)
Comments Part of: MD Anderson Cell Lines Project.
From: Immuno-Biological Laboratories (IBL); Tokyo; Japan.
Sequence variation: EGFR p.Glu746_Ala750del (PubMed=17332333).
Omics: Deep membrane proteome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis.
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_1640 (PC-14); CVCL_S706 (PC-9-GR-high); CVCL_S707 (PC-9-GR-step); CVCL_T015 (PC-9/BR); CVCL_DG28 (PC-9/ER/WR); CVCL_D778 (PC-9/ER1); CVCL_D726 (PC-9/ER3); CVCL_U149 (PC-9/f14); CVCL_U150 (PC-9/f9); CVCL_DI28 (PC-9/GR1); CVCL_DI29 (PC-9/GR2); CVCL_DI30 (PC-9/GR3); CVCL_DH34 (PC-9/GR4); CVCL_DI31 (PC-9/GR5); CVCL_DI32 (PC-9/GR6); CVCL_DG27 (PC-9/GR/WR); CVCL_DP47 (PC-9/IR); CVCL_S750 (PC-9/R); CVCL_T016 (PC-9/S2); CVCL_DG29 (PC-9/WR); CVCL_V337 (PC-9/ZD); CVCL_S977 (PC9-DPE2); CVCL_B263 (RPC-9)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D13S3178
D16S5399
D18S5115
D19S43313,15.2
D21S1130
D2S133819,20
D3S135816
D5S81811
D7S82010,11
D8S117911,15
FGA23
Penta D13
Penta E11
TH017
TPOX11
vWA17
Web pages http://tcpaportal.org/mclp/
Publications

DOI=10.5795/jjscc.24.451
Tsumuraya M., Nakajima T., Terasaki T., Kodama T., Shimosato Y., Higuchi H., Uei Y.
Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.
J. Jpn. Soc. Clin. Cytol. 24:451-456(1985)

PubMed=4094096
Lee Y.-C., Saijo N., Sasaki Y., Takahashi H., Sakurai M., Ishihara J., Hoshi A., Chen K.-M., Hamburger A.W.
Clonogenic patterns of human pulmonary adenocarcinoma cell lines (PC-9, PC-13 and PC-14) and how they influence the results of test for chemosensitivity to cisplatin in the human tumor clonogenic assay.
Jpn. J. Clin. Oncol. 15:637-644(1985)

PubMed=11005564; DOI=10.1038/sj.neo.7900094
Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M., Yokota J.
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=11078804; DOI=10.3892/ijo.17.6.1187
Takenaka K., Shibuya M., Takeda Y., Hibino S., Gemma A., Ono Y., Kudoh S.
Altered expression and function of beta1 integrins in a highly metastatic human lung adenocarcinoma cell line.
Int. J. Oncol. 17:1187-1194(2000)

PubMed=17332333; DOI=10.1158/0008-5472.CAN-06-3339
Okabe T., Okamoto I., Tamura K., Terashima M., Yoshida T., Satoh T., Takada M., Fukuoka M., Nakagawa K.
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.
Cancer Res. 67:2046-2053(2007)

PubMed=19472407; DOI=10.1002/humu.21028
Blanco R., Iwakawa R., Tang M., Kohno T., Angulo B., Pio R., Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=22313637; DOI=10.4161/cbt.19238
Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A., Igishi T., Burioka N., Nanba E., Shimizu E.
Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.
Cancer Biol. Ther. 13:369-378(2012)

PubMed=23733853; DOI=10.1101/gr.152322.112
Jia P., Jin H., Meador C.B., Xia J., Ohashi K., Liu L., Pirazzoli V., Dahlman K.B., Politi K., Michor F., Zhao Z., Pao W.
Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.
Genome Res. 23:1434-1445(2013)

PubMed=26202522; DOI=10.1021/acs.jproteome.5b00477
Kitata R.B., Dimayacyac-Esleta B.R., Choong W.-K., Tsai C.-F., Lin T.-D., Tsou C.-C., Weng S.-H., Chen Y.-J., Yang P.-C., Arco S.D., Nesvizhskii A.I., Sung T.-Y., Chen Y.-J.
Mining missing membrane proteins by high-pH reverse-phase stagetip fractionation and multiple reaction monitoring mass spectrometry.
J. Proteome Res. 14:3658-3669(2015)

PubMed=26554430; DOI=10.1021/acs.analchem.5b03639
Dimayacyac-Esleta B.R., Tsai C.-F., Kitata R.B., Lin P.-Y., Choong W.-K., Lin T.-D., Wang Y.-T., Weng S.-H., Yang P.-C., Arco S.D., Sung T.-Y., Chen Y.-J.
Rapid high-pH reverse phase stagetip for sensitive small-scale membrane proteomic profiling.
Anal. Chem. 87:12016-12023(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections BCRJ; 0331
RCB; RCB4455
Cell line databases/resources IGRhCellID; PC9GEO
LINCS_HMS; 50038
LINCS_LDP; LCL-1630
Ontologies BTO; BTO:0005518
CLO; CLO_0050067
EFO; EFO_0002847
Biological sample resources BioSample; SAMN03470946
ENCODE; ENCBS177ANS
ENCODE; ENCBS480XRH
ENCODE; ENCBS761VSF
ENCODE; ENCBS987JQH
Chemistry resources ChEMBL-Cells; CHEMBL3307867
ChEMBL-Targets; CHEMBL614102
Gene expression databases GEO; GSM434290
GEO; GSM481160
GEO; GSM784274
GEO; GSM794406
GEO; GSM827407
GEO; GSM1374821
Polymorphism and mutation databases Cosmic; 713867
Cosmic; 801574
Cosmic; 876137
Cosmic; 897746
Cosmic; 911753
Cosmic; 915329
Cosmic; 917985
Cosmic; 929156
Cosmic; 946058
Cosmic; 1001658
Cosmic; 1002731
Cosmic; 1047092
Cosmic; 1128254
Cosmic; 1146943
Cosmic; 1239896
Cosmic; 1336875
Cosmic; 1571735
Cosmic; 1656893
Cosmic; 1731370
Cosmic; 1745414
Cosmic; 2015224
Cosmic; 2125285
Proteomic databases PRIDE; PXD001548
PRIDE; PXD002224