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Cellosaurus HPAF (CVCL_B284)

[Text version]

Cell line name HPAF
Synonyms HPAF-I
Accession CVCL_B284
Resource Identification Initiative To cite this cell line use: HPAF (RRID:CVCL_B284)
Sequence variations Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=8026879; PubMed=8426738).
Mutation; HGNC; 11998; TP53; Simple; p.Pro151Ser (c.451C>T); ClinVar=VCV000012370; Zygosity=Homozygous (PubMed=8026879; PubMed=8426738).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Male
Age at sampling 44Y
Category Cancer cell line

Metzgar R.S., Gaillard M.T., Levine S.J., Tuck F.L., Bossen E.H., Borowitz M.J.
Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies.
Cancer Res. 42:601-608(1982)

Kalthoff H., Schmiegel W., Roeder C., Kasche D., Schmidt A., Lauer G., Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E., Maurer J., Maacke H., Deppert W.
p53 and K-RAS alterations in pancreatic epithelial cell lesions.
Oncogene 8:289-298(1993)

PubMed=8026879; DOI=10.1002/ijc.2910580207
Berrozpe G., Schaeffer J., Peinado M.A., Real F.X., Perucho M.
Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.
Int. J. Cancer 58:185-191(1994)

PubMed=11169957; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1014>3.0.CO;2-U
Wallrapp C., Hahnel S., Boeck W., Soder A., Mincheva A., Lichter P., Leder G., Gansauge F., Sorio C., Scarpa A., Gress T.M.
Loss of the Y chromosome is a frequent chromosomal imbalance in pancreatic cancer and allows differentiation to chronic pancreatitis.
Int. J. Cancer 91:340-344(2001)

Other Wikidata; Q54890230
Polymorphism and mutation databases Cosmic; 724640
Cosmic; 736274
Cosmic; 808174
Cosmic; 872999
Cosmic; 922245
Cosmic; 933527
Cosmic; 948376
Cosmic; 948735
IARC_TP53; 28521
Entry history
Entry creation06-Jun-2012
Last entry update20-May-2021
Version number12