ID   HPAF
AC   CVCL_B284
SY   HPAF-I
DR   cancercelllines; CVCL_B284
DR   Cosmic; 724640
DR   Cosmic; 736274
DR   Cosmic; 808174
DR   Cosmic; 872999
DR   Cosmic; 922245
DR   Cosmic; 933527
DR   Cosmic; 948376
DR   Cosmic; 948735
DR   IARC_TP53; 28521
DR   Wikidata; Q54890230
RX   PubMed=7034925;
RX   PubMed=8026879;
RX   PubMed=8194712;
RX   PubMed=8426738;
RX   PubMed=11169957;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=8026879; PubMed=8426738).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro151Ser (c.451C>T); ClinVar=VCV000012370; Zygosity=Homozygous (PubMed=8026879; PubMed=8194712; PubMed=8426738).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   44Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 16
//
RX   PubMed=7034925;
RA   Metzgar R.S., Gaillard M.T., Levine S.J., Tuck F.L., Bossen E.H.,
RA   Borowitz M.J.;
RT   "Antigens of human pancreatic adenocarcinoma cells defined by murine
RT   monoclonal antibodies.";
RL   Cancer Res. 42:601-608(1982).
//
RX   PubMed=8026879; DOI=10.1002/ijc.2910580207;
RA   Berrozpe G., Schaeffer J., Peinado M.A., Real F.X., Perucho M.;
RT   "Comparative analysis of mutations in the p53 and K-ras genes in
RT   pancreatic cancer.";
RL   Int. J. Cancer 58:185-191(1994).
//
RX   PubMed=8194712; DOI=10.1016/0016-5085(94)90422-7;
RA   Simon B., Weinel R., Hohne M., Watz J., Schmidt J., Kortner G.,
RA   Arnold R.;
RT   "Frequent alterations of the tumor suppressor genes p53 and DCC in
RT   human pancreatic carcinoma.";
RL   Gastroenterology 106:1645-1651(1994).
//
RX   PubMed=8426738;
RA   Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G.,
RA   Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E.,
RA   Maurer J., Maacke H., Deppert W.;
RT   "p53 and K-RAS alterations in pancreatic epithelial cell lesions.";
RL   Oncogene 8:289-298(1993).
//
RX   PubMed=11169957; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1014>3.0.CO;2-U;
RA   Wallrapp C., Hahnel S., Boeck W., Soder A., Mincheva A., Lichter P.,
RA   Leder G., Gansauge F., Sorio C., Scarpa A., Gress T.M.;
RT   "Loss of the Y chromosome is a frequent chromosomal imbalance in
RT   pancreatic cancer and allows differentiation to chronic
RT   pancreatitis.";
RL   Int. J. Cancer 91:340-344(2001).
//