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Cellosaurus KPD (CVCL_B412)

[Text version]
Cell line name KPD
Synonyms KPDXM
Accession CVCL_B412
Resource Identification Initiative To cite this cell line use: KPD (RRID:CVCL_B412)
Comments Doubling time: ~36 hours (PubMed=21519327).
Omics: SNP array analysis.
Caution: Indicated as originating from a 7 year old female patient in PubMed=19787792 and from a 8 year old male patient in PubMed=17354236. The STR profile has Amelogenin X,Y.
Derived from site: In situ; Bone, femur; UBERON=UBERON_0000981.
Sequence variations
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=19787792).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792

Markers:
AmelogeninX,Y
D2S133820,24
D3S135817
D5S8189,11
D8S117913,15
D16S53911,13
D18S5110,13
D19S43313.2,14
D21S1130,31.2
FGA21
SE3327.2
TH019,9.3
TPOX8,9
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=2457439
Bruland O.S., Fodstad O., Stenwig A.E., Pihl A.
Expression and characteristics of a novel human osteosarcoma-associated cell surface antigen.
Cancer Res. 48:5302-5309(1988)

PubMed=17354236; DOI=10.1002/ijc.22643
Muller C.R., Paulsen E.B., Noordhuis P., Pedeutour F., Saeter G., Myklebost O.
Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A.
Int. J. Cancer 121:199-205(2007)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21519327; DOI=10.1038/labinvest.2011.72
Mohseny A.B., Machado I., Cai Y.-P., Schaefer K.-L., Serra M., Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
Lab. Invest. 91:1195-1205(2011)

PubMed=23144859; DOI=10.1371/journal.pone.0048262
Kresse S.H., Rydbeck H., Skarn M., Namlos H.M., Barragan-Polania A.H., Cleton-Jansen A.-M., Serra M., Liestol K., Hogendoorn P.C.W., Hovig E., Myklebost O., Meza-Zepeda L.A.
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma.
PLoS ONE 7:E48262-E48262(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B412
Anatomy/cell type resources BTO; BTO:0006421
Encyclopedic resources Wikidata; Q54900430
Gene expression databases GEO; GSM879216
Polymorphism and mutation databases Cosmic; 1529900
IARC_TP53; 27030
Progenetix; CVCL_B412
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number16