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Cellosaurus MHM (CVCL_B426)

Cell line name MHM
Synonyms MHMX
Accession CVCL_B426
Resource Identification Initiative To cite this cell line use: MHM (RRID:CVCL_B426)
Comments Doubling time: ~60 hours (PubMed=21519327).
Omics: SNP array analysis.
Derived from site: In situ; Bone, pelvis; UBERON=UBERON_0012179.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=19787792).
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=19787792).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 41Y
Category Cancer cell line
STR profile Source(s): PubMed=19787792

Markers:
AmelogeninX
D2S133819,24
D3S135817,18
D5S81812,13
D8S117910,13
D16S5399,13
D18S5112,14
D19S43314,15
D21S1130.2,32
FGA19,23
SE3324.2
TH019.3
TPOX9,12
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=8198963; DOI=10.1038/bjc.1994.200
Kjonniksen I., Rye P.D., Fodstad O.
Helix pomatia agglutinin binding in human tumour cell lines: correlation with pulmonary metastases in nude mice.
Br. J. Cancer 69:1021-1024(1994)

PubMed=17354236; DOI=10.1002/ijc.22643
Muller C.R., Paulsen E.B., Noordhuis P., Pedeutour F., Saeter G., Myklebost O.
Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A.
Int. J. Cancer 121:199-205(2007)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21519327; DOI=10.1038/labinvest.2011.72
Mohseny A.B., Machado I., Cai Y.-P., Schaefer K.-L., Serra M., Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
Lab. Invest. 91:1195-1205(2011)

PubMed=23144859; DOI=10.1371/journal.pone.0048262
Kresse S.H., Rydbeck H., Skarn M., Namlos H.M., Barragan-Polania A.H., Cleton-Jansen A.-M., Serra M., Liestol K., Hogendoorn P.C.W., Hovig E., Myklebost O., Meza-Zepeda L.A.
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma.
PLoS ONE 7:E48262-E48262(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B426
Anatomy/cell type resources BTO; BTO:0006420
Encyclopedic resources Wikidata; Q54905565
Gene expression databases GEO; GSM879218
Polymorphism and mutation databases Cosmic; 1529904
IARC_TP53; 27031
Progenetix; CVCL_B426
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number16