ID   NPLC/PRF/5
AC   CVCL_B449
SY   N-PLC/PRF/5
DR   BTO; BTO:0002906
DR   cancercelllines; CVCL_B449
DR   Wikidata; Q54930996
RX   PubMed=2827003;
CC   Population: African; Shangaan.
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg112Gly (c.334C>G) (p.Pro126Arg, c.377C>G); ClinVar=VCV000233484; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12363; TSC2; Simple; p.Asn1651Ser (c.4952A>G); ClinVar=VCV000049335; Zygosity=Homozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0485 ! PLC/PRF/5
SX   Male
AG   24Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 17
//
RX   PubMed=2827003; DOI=10.1128/mcb.8.1.25-34.1988;
RA   Carlin C.R., Simon D., Mattison J., Knowles B.B.;
RT   "Expression and biosynthetic variation of the epidermal growth factor
RT   receptor in human hepatocellular carcinoma-derived cell lines.";
RL   Mol. Cell. Biol. 8:25-34(1988).
//